Journal Article

Cellular Partners of Tobamoviral Movement Proteins

Ershova, Natalia M., Komarova, Tatiana V., Sheshukova, Ekaterina V., Kamarova, Kamila A.

2025

Overview

The size of viral genomes is limited, thus the majority of encoded proteins possess multiple functions. The main function of tobamoviral movement protein (MP) is to perform plasmodesmata gating and mediate intercellular transport of the viral RNA. MP is a remarkable example of a protein that, in addition to the initially discovered and most obvious function, carries out numerous activities that are important both for the manifestation of its key function and for successful and productive infection in general. Briefly, MP binds the viral genome, delivers it to the plasmodesmata (PD) and mediates its intercellular transfer. To implement the transport function, MP interacts with diverse cellular factors. Each of these cellular proteins has its own function, which could be different under normal conditions and upon viral infection. Here, we summarize the data available at present on the plethora of cellular factors that were identified as tobamoviral MP partners and analyze the role of these interactions in infection development.

• Publisher: MDPI AG,MDPI
• Subject: Cytoskeleton / Endoplasmic reticulum / Enzymes / Genes / Genomes / Host-Pathogen Interactions / Humans / Immunity (Disease) / Infections / Kinases / Pathogens / Plant resistance / Plant Viral Movement Proteins - genetics / Plant Viral Movement Proteins - metabolism / Plasmodesmata - metabolism / Plasmodesmata - virology / Proteins / Review / Signal transduction / Tobamovirus - genetics / Tobamovirus - metabolism / Tobamovirus - physiology / Viral infections / Virulence / Viruses