Journal Article

Health-Related Quality of Life in Australasian Survivors of H1N1 Influenza Undergoing Mechanical Ventilation. A Multicenter Cohort Study

Hodgson, Carol L., Haines, Kimberley J., Ryan, Danielle T., Mulvany, Kate, Denehy, Linda, Berney, Sue, Howe, Belinda, Seller, Daniel, Di Marco, Emma, McArthur, Colin J., Skinner, Elizabeth H.

2015

Overview

Patients surviving acute respiratory distress syndrome suffer decrements in physical function and health-related quality of life (HR-QoL); however, it is unclear whether HR-QoL is disproportionately affected in those with H1N1 influenza. The objective was to compare the HR-QoL of patients with a diagnosis of H1N1 influenza who were mechanically ventilated, 12 months after intensive care unit (ICU) discharge with healthy population data and ICU survivor data. A prospective, observational, binational, multicenter cohort study was conducted in 11 ICUs in Australia and New Zealand during June-September 2009. Eligible participants were mechanically ventilated in the ICU with a confirmed diagnosis of H1N1 influenza. People were excluded if they were less than 18 years of age or could not speak English. Two validated HR-QoL questionnaires (Short Form-36 version 2 [SF-36], and Assessment of Quality of Life [AQoL]) were administered 1 year after ICU discharge. Sixty-two patients (48% male) had a median (interquartile range) age of 42 (29-53) years and an APACHE II score of 18.0 (14-20); ventilation days, 10.0 (4-23); and ICU and hospital length of stay, 12.5 (7-27) and 20.0 (15-38) days, respectively. Hospital mortality was 7%, and 31% of the cohort received a tracheostomy. The mean (SD) health utility score at 1 year was 0.68 (0.30) compared with the healthy age-matched population (0.81 [0.23]). The mean (SD) SF-36 physical and mental component summary scores were within population normal ranges at 44.4 (12.3) and 45.5 (12.5), respectively. Health-related quality of life of Australasian survivors of severe H1N1 influenza was comparable to the healthy population 1 year after ICU discharge. Consensus should be sought on standardization of follow-up time points and outcome measurement. Clinical trial registered with the Australian and New Zealand Clinical Trials Registry (ACTRN12609001037291).

• Publisher: Oxford University Press
• Subject: Adult / Australia - epidemiology / Female / Follow-Up Studies / Humans / Influenza A Virus, H1N1 Subtype - isolation & purification / Influenza, Human - complications / Influenza, Human - diagnosis / Influenza, Human - epidemiology / Influenza, Human - physiopathology / Influenza, Human - virology / Male / Middle Aged / New Zealand - epidemiology / Outcome Assessment (Health Care) / Quality of Life / Respiration, Artificial - methods / Respiratory Distress Syndrome, Adult - diagnosis / Respiratory Distress Syndrome, Adult - epidemiology / Respiratory Distress Syndrome, Adult - etiology / Respiratory Distress Syndrome, Adult - therapy / Surveys and Questionnaires / Survivors - psychology