Journal Article

Strategic Plan for Lung Vascular Research

Oka, Masahiko, McMurtry, Ivan F., Stevens, Troy, Gail, Dorothy, Moore, Timothy M., Bauer, Natalie, Fagan, Karen, Schumacker, Paul, Weinshilboum, Richard, Zhao, Yingming, Dorn, Gerald W., Rodman, David, Kawut, Steven M., Rounds, Sharon I., Geraci, Mark, Gladwin, Mark T., Archer, Stephen L., Dweik, Raed, Finkel, Toren, Humbert, Marc, Newman, John, Stenmark, Kurt, Asosingh, Kewal, Rabinovitch, Marlene, Fallon, Michael, Bhattacharya, Jahar, McDonald, Donald, Tuder, Rubin, Aldred, Micheala, Choudhary, Gaurav, Aliotta, Jason, Kaminski, Naftali, Shizuru, Judy, Sullivan, Eugene, Hassoun, Paul M., Nicolls, Mark, Polgar, Peter, Yoder, Mervin C., Bogaard, Harm, Balaban, Robert, Loscalzo, Joseph, Voelkel, Norbert, Erzurum, Serpil

2010

Overview

The Division of Lung Diseases of the National Heart, Lung, and Blood Institute, with the Office of Rare Diseases Research, held a workshop to identify priority areas and strategic goals to enhance and accelerate research that will result in improved understanding of the lung vasculature, translational research needs, and ultimately the care of patients with pulmonary vascular diseases. Multidisciplinary experts with diverse experience in laboratory, translational, and clinical studies identified seven priority areas and discussed limitations in our current knowledge, technologies, and approaches. The focus for future research efforts include the following: (1) better characterizing vascular genotype-phenotype relationships and incorporating systems biology approaches when appropriate; (2) advancing our understanding of pulmonary vascular metabolic regulatory signaling in health and disease; (3) expanding our knowledge of the biologic relationships between the lung circulation and circulating elements, systemic vascular function, and right heart function and disease; (4) improving translational research for identifying disease-modifying therapies for the pulmonary hypertensive diseases; (5) establishing an appropriate and effective platform for advancing translational findings into clinical studies testing; and (6) developing the specific technologies and tools that will be enabling for these goals, such as question-guided imaging techniques and lung vascular investigator training programs. Recommendations from this workshop will be used within the Lung Vascular Biology and Disease Extramural Research Program for planning and strategic implementation purposes.

• Publisher: American Thoracic Society,Oxford University Press
• Subject: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy / Biological and medical sciences / Biology / Biomedical Research - methods / Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine / Epigenetics / Gene expression / Guidelines as Topic / Humans / Intensive care medicine / Kinases / Lung - blood supply / Lung diseases / Lung Diseases - physiopathology / Medical sciences / Mutation / Nhlbi Workshop / Proteins / Pulmonary arteries / Pulmonary Circulation / Pulmonary hypertension