Journal Article

Peroral Endoscopic Myotomy for the Treatment of Achalasia: A Prospective Single Center Study

Rösch, Thomas, Werner, Yuki Birgit, von Renteln, Daniel, Minami, Hiromi, Much, Chressen Catharina, Mann, Oliver, Keller, Jutta, Inoue, Haruhiro, Fuchs, Karl-Hermann, Pace, Andrea, Kersten, Jan Felix, Schachschal, Guido

2012

Overview

Endoscopic balloon dilatation and laparoscopic myotomy are established treatments for achalasia. Recently, a new endoscopic technique for complete myotomy was described. Herein, we report the results of the first prospective trial of peroral endoscopic myotomy (POEM) in Europe. POEM was performed under general anesthesia in 16 patients (male:female (12:4), mean age 45 years, range 26-76). The primary outcome was symptom relief at 3 months, defined as an Eckhard score ≤3. Secondary outcomes were procedure-related adverse events, lower esophageal sphincter (LES) pressure on manometry, reflux symptoms, and medication use before and after POEM. A 3-month follow-up was completed for all patients. Treatment success (Eckhard score ≤3) was achieved in 94% of cases (mean score pre- vs. post-treatment (8.8 vs. 1.4); P<0.001). Mean LES pressure was 27.2 mm Hg pre-treatment and 11.8 mm Hg post-treatment (P<0.001). No patient developed symptoms of gastro-esophageal reflux after treatment, but one patient was found to have an erosive lesion (LA grade A) on follow-up esophagogastroduodenoscopy. No patient required medication with proton pump inhibitors or antacids after POEM. POEM is a promising new treatment for achalasia resulting in short-term symptom relief in >90% of cases. Studies evaluating long-term efficacy and comparing POEM with established treatments have been initiated.

• Publisher: Nature Publishing Group,Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subject: Adult / Aged / Biological and medical sciences / Esophageal Achalasia - diagnosis / Esophageal Achalasia - surgery / Esophagoscopy / Esophagus / Esophagus - surgery / Female / Gastroenterology / Gastroenterology. Liver. Pancreas. Abdomen / Humans / Length of Stay - statistics & numerical data / Male / Malformations / Manometry / Medical sciences / Middle Aged / Natural Orifice Endoscopic Surgery - methods / Prospective Studies / Treatment Outcome