Asset Details
Do you wish to reserve the book?
When nanozymes meet deoxyribonucleic acid: Understanding their interactions and biomedical diagnosis applications
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
When nanozymes meet deoxyribonucleic acid: Understanding their interactions and biomedical diagnosis applications
Do you wish to request the book?
When nanozymes meet deoxyribonucleic acid: Understanding their interactions and biomedical diagnosis applications
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
When nanozymes meet deoxyribonucleic acid: Understanding their interactions and biomedical diagnosis applications
2024
Overview
As emerging alternatives to natural enzymes, nanoscale materials featuring enzyme‐like catalytic behaviors (nanozymes) exhibit some attractive merits including robust activity, low cost, and easy‐to‐regulate performance. These merits have enabled them to be intensively used in the biomedical field in recent years. To remedy the lack of catalytic selectivity in most nanozymes, deoxyribonucleic acid (DNA) chains with specific recognition functions are utilized to integrate with nanozymes to produce various nanozyme–DNA combinations via adsorption/desorption. In the formed combinations, the DNA component provides the molecular/ionic recognition role, and the nanozyme part offers response with catalytically amplified signals, enabling them to detect analytes and biomarkers selectively and sensitively. To highlight this interesting topic, here we made a critical review of the interactions between nanozymes and DNA and their applications in biosensing and disease diagnosis. First, strategies for the conjugation of DNA chains onto nanozyme surface were introduced briefly. Then, the interactions between DNA and nanozymes were summarized in detail, where flexible modulations of nanozyme activity by DNA adsorption/desorption as well as various factors were analyzed, and potential impacts caused by nanozymes on the recognition characteristics of DNA chains were pointed out. After that, typical applications of DNA‐mediated nanozyme modulation in toxic ion sensing, health risk factor monitoring, and biomedical diagnosis were introduced. In the end, prospects of the combination of nanozymes and DNA chains were presented, and future challenges of the emerging field were also discussed, to attract more interest and effort to advance this promising area.
This critical review highlights the interactions between nanozymes and deoxyribonucleic acid (DNA) and their applications in biosensing and disease diagnosis. First, strategies for the conjugation of DNA chains onto nanozyme surfaces are introduced briefly. Then, the interactions between DNA and nanozymes are summarized in detail, where flexible modulations of nanozyme activity by DNA adsorption/desorption as well as various factors are analyzed, and potential impacts caused by nanozymes on the recognition characteristics of DNA chains are pointed out. After that, typical applications of DNA‐mediated nanozyme modulation in toxic ion sensing, health risk factor monitoring, and biomedical diagnosis are introduced. In the end, prospects of the combination of nanozymes and DNA chains are presented, and future challenges of the emerging field are also discussed.
