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Evaluation of Stopping Power Ratio Calculation Using Dual-energy Computed Tomography With Fast Kilovoltage Switching for Treatment Planning of Particle Therapy
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Evaluation of Stopping Power Ratio Calculation Using Dual-energy Computed Tomography With Fast Kilovoltage Switching for Treatment Planning of Particle Therapy
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Journal Article
Evaluation of Stopping Power Ratio Calculation Using Dual-energy Computed Tomography With Fast Kilovoltage Switching for Treatment Planning of Particle Therapy
2022
Overview
This study evaluated the calculation accuracy of the stopping power ratio (SPR) using dual-energy computed tomography with fast kilovoltage switching (FKSCT) for particle therapy.
A tissue characterization phantom with various reference materials was scanned to obtain single-energy computed tomography (SECT) images and generate virtual monochromatic images at 77 keV (VMI
) and 140 keV (VMI
), water density (WD) images, and effective Z (Z
) images. For SECT, VMI
and VMI
lookup tables were generated to convert the measured Hounsfield value into the theoretical SPR for a normal phantom size. Subsequently, the reference materials were scanned in small and large phantoms. The SPR was calculated using the lookup tables of SECT (SPR
) images, VMI
(SPR
), and VMI
(SPR
), and it was derived from the WD and Z
(SPR
).
In the normal-sized phantom, the overall mean difference between SPR
and theoretical SPR was -0.3%, and remained below 2% for most reference materials. For the large phantom, the overall mean absolute difference for SPR
(3.0%, p=0.006) and SPR
(3.2%, p=0.002) for the reference materials was significantly lower than that for SPR
(5.9%). For the small phantom, a significant reduction in the mean difference in the SPR calculation was observed in SPR
(1.0%, p=0.001) and SPR
(1.1%, p=0.013) compared with SPR
(2.2%).
VMI
generated using FKSCT significantly improves the estimation accuracy of SPR compared with SECT. Thus, FKSCT may be used to improve the dose calculation accuracy for treatment planning of particle therapy.
Publisher
International Institute of Anticancer Research
Subject
