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Decreases in Inflammatory and Coagulation Biomarkers Levels in HIV-Infected Patients Switching from Enfuvirtide to Raltegravir: ANRS 138 Substudy
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Decreases in Inflammatory and Coagulation Biomarkers Levels in HIV-Infected Patients Switching from Enfuvirtide to Raltegravir: ANRS 138 Substudy
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Journal Article
Decreases in Inflammatory and Coagulation Biomarkers Levels in HIV-Infected Patients Switching from Enfuvirtide to Raltegravir: ANRS 138 Substudy
2013
Overview
Stored plasma specimens from 164 participants in the ANRS 138 trial were analyzed to determine interleukin 6 (IL-6), high-sensitivity C-reactive protein (hsCRP), and D-dimer levels at baseline and weeks 24 and 48. These virologically suppressed, treatment-experienced patients were randomly assigned to undergo an immediate switch (IS) or a deferred switch (DS; at week 24) from an enfuvirtide-based antiretroviral therapy (ART) regimen to a raltegravir-based regimen. At week 24, a significant decrease from baseline was observed in the IS arm, compared with the DS arm, for IL–6 level (–30% vs + 10%; P<. 002), hsCRP level (–46% vs + 15%; P< .0001), and D-dimer level (–40% vs + 6%; P<.0001). At week 48, there was a reproducible decrease in levels of all biomarkers in the DS arm.
Publisher
Oxford University Press
Subject
/ AIDS
/ Anti-HIV Agents - therapeutic use
/ Biological and medical sciences
/ Blood Coagulation - drug effects
/ C-Reactive Protein - analysis
/ Female
/ Fibrin Fibrinogen Degradation Products - analysis
/ Fundamental and applied biological sciences. Psychology
/ HIV
/ HIV Envelope Protein gp41 - therapeutic use
/ HIV Infections - drug therapy
/ HIV-1
/ HIV/AIDS
/ Humans
/ Male
/ Peptide Fragments - therapeutic use
/ Pyrrolidinones - therapeutic use
/ RNA
