Asset Details
Do you wish to reserve the book?
Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology
Do you wish to request the book?
Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology
2024
Overview
INTRODUCTION Factors responsible for the deposition of pathological tau in the brain are incompletely understood. This study links macroscale tau deposition in the human brain to cerebrospinal fluid (CSF) flow dynamics using resting‐state functional magnetic resonance imaging (rsfMRI). METHODS Low‐frequency (< 0.1 Hz) resting‐state global brain activity is coupled with CSF flow and potentially reflects CSF dynamics‐related clearance. We examined the correlation between rsfMRI measures of CSF inflow and global activity (gBOLD–CSF coupling) as a predictor, interacting with amyloid beta (Aβ), of tau and cortical thickness (dependent variables) across Alzheimer's Disease Neuroimaging Initiative (ADNI) participants from cognitively unimpaired through mild cognitive impairment (MCI) and Alzheimer's disease (AD). RESULTS Tau deposition in Aβ+ participants, accompanied by cortical thinning and cognitive decline, is associated with decreased gBOLD–CSF coupling. Tau mediates the relationship between coupling and thickness. DISCUSSION Findings suggest that resting‐state global brain activity and CSF movements comodulate Alzheimer's tau deposition, presumably related to CSF clearance. Highlights A non‐invasive functional magnetic resonance imaging (fMRI) assessment of a CSF clearance‐related process is carried out. Global brain activity is coupled with CSF inflow in human fMRI during resting state. Global fMRI–CSF coupling is correlated with tau in Alzheimer's disease (AD). This coupling measure is also associated with cortical thickness, mediated by tau.
Publisher
John Wiley and Sons Inc
Subject
/ Alzheimer Disease - cerebrospinal fluid
/ Alzheimer Disease - diagnostic imaging
/ Alzheimer Disease - physiopathology
/ Alzheimer's disease pathology
/ Amyloid beta-Peptides - cerebrospinal fluid
/ cerebrospinal fluid (CSF) flow
/ Cerebrospinal Fluid - physiology
/ Cognitive Dysfunction - cerebrospinal fluid
/ Cognitive Dysfunction - physiopathology
/ CSF dynamics‐related clearance
/ Female
/ global resting‐state fMRI signal
/ Humans
/ Male
