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Successful treatment of blepharitis with bibrocathol (Posiformin® 2 %)
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Successful treatment of blepharitis with bibrocathol (Posiformin® 2 %)
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Journal Article
Successful treatment of blepharitis with bibrocathol (Posiformin® 2 %)
2012
Overview
Background
Bibrocathol is a well-established antiseptic drug for the treatment of acute eyelid diseases like blepharitis. Despite its frequent use in clinical practice, no controlled clinical trial on the efficacy of bibrocathol 2% eye ointment has been performed until now. The aim of the study was to investigate efficacy, safety and tolerability of bibrocathol (Posiformin® 2 %) eye ointment in patients diagnosed with blepharitis.
Methods
In this multi-center, randomized, double-masked, placebo-controlled parallel-group comparison, the change of signs and symptoms (sum score) of blepharitis in 197 patients (ITT (intention-to-treat-group); mean age 56 ± 18 years, 56 % female, active drug:vehicle = 97:100) over 2 weeks treatment with bibrocathol 2 % eye ointment was evaluated.
Results
Patients receiving bibrocathol 2 % showed greater improvement in the sum score than the placebo patients (
p
< 0.0001, Cohen’s effect size d = 0.73). Also, the results from further efficacy assessments improvement of single symptoms and ocular discomfort measured by a VAS (visual analogue scale) supported treatment with bibrocathol. Patients and investigators provided favorable tolerability ratings preferring bibrocathol over placebo. No safety issues were observed with regard to intraocular pressure, visual acuity, or occurrence of adverse events.
Conclusions
Blepharitis therapy with the antiseptic bibrocathol 2 % in this trial was highly efficacious and safe.
Publisher
Springer-Verlag,Springer Nature B.V
