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Tirzepatide for Metabolic Dysfunction–Associated Steatohepatitis with Liver Fibrosis

by Loomba, Rohit , Haupt, Axel , Robins, Deborah A. , Bunck, Mathijs C. , Tang, Yuanyuan , Hartman, Mark L. , Vuppalanchi, Raj , Boursier, Jérôme , Bugianesi, Elisabetta , Brouwers, Bram , Behling, Cynthia , Lawitz, Eric J. , Cummings, Oscar W. , Yoneda, Masato , Nikooie, Amir , Sanyal, Arun J.

in Adult / Aged / Antidiabetics / Biomarkers / Biopsy / Clinical trials / Diabetes / Dose-Response Relationship, Drug / Double-Blind Method / Endocrinology / Endocrinology General / Fatty Liver - drug therapy / Female / Fibrosis / Gastric Inhibitory Polypeptide - agonists / Gastroenterology / Gastroenterology General / Gastrointestinal surgery / GIP protein / Glucagon / Glucagon-like peptide 1 / Glucagon-Like Peptide-1 Receptor Agonists / Glucagon-Like Peptide-2 Receptor - agonists / Humans / Inflammation / Injections, Subcutaneous / Life Sciences / Liver - drug effects / Liver - pathology / Liver cirrhosis / Liver Cirrhosis - drug therapy / Liver Disease / Liver diseases / Magnetic resonance imaging / Male / Metabolism / Middle Aged / Obesity / Placebos / Software / Tirzepatide

2024

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Tirzepatide for Metabolic Dysfunction–Associated Steatohepatitis with Liver Fibrosis

2024

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Tirzepatide for Metabolic Dysfunction–Associated Steatohepatitis with Liver Fibrosis

2024

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Journal Article

Tirzepatide for Metabolic Dysfunction–Associated Steatohepatitis with Liver Fibrosis

Loomba, Rohit,

Haupt, Axel,

Robins, Deborah A.,

Bunck, Mathijs C.,

Tang, Yuanyuan,

Hartman, Mark L.,

Vuppalanchi, Raj,

Boursier, Jérôme,

Bugianesi, Elisabetta,

Brouwers, Bram,

Behling, Cynthia,

Lawitz, Eric J.,

Cummings, Oscar W.,

Yoneda, Masato,

Nikooie, Amir,

Sanyal, Arun J.

2024

Overview

In this phase 2 trial in patients with metabolic dysfunction–associated steatohepatitis and moderate or severe fibrosis, tirzepatide was more effective than placebo with respect to resolution of MASH without worsening of fibrosis.

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Publisher

Massachusetts Medical Society

Subject

/ Aged

/ Biopsy