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Hippocampus and olfactory impairment in Parkinson disease: a comparative exploratory combined volumetric/functional MRI study
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Hippocampus and olfactory impairment in Parkinson disease: a comparative exploratory combined volumetric/functional MRI study
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Journal Article
Hippocampus and olfactory impairment in Parkinson disease: a comparative exploratory combined volumetric/functional MRI study
2024
Overview
Introduction
Patients with Parkinson’s Disease (PD) commonly experience Olfactory Dysfunction (OD). Our exploratory study examined hippocampal volumetric and resting-state functional magnetic resonance imaging (rs-fMRI) variations in a Healthy Control (HC) group versus a cognitively normal PD group, further categorized into PD with No/Mild Hyposmia (PD-N/MH) and PD with Severe Hyposmia (PD-SH).
Methods
We calculated participants’ relative Total Hippocampal Volume (rTHV) and performed Spearman’s partial correlations, controlled for age and gender, to examine the correlation between rTHV and olfactory performance assessed by the Odor Stick Identification Test for the Japanese (OSIT-J) score. Mann-Whitney U tests assessed rTHV differences across groups and subgroups, rejecting the null hypothesis for
p
< 0.05. Furthermore, a seed-based rs-fMRI analysis compared hippocampal connectivity differences using a one-way ANCOVA covariate model with controls for age and gender.
Results
Spearman’s partial correlations indicated a moderate positive correlation between rTHV and OSIT-J in the whole study population (ρ = 0.406;
p
= 0.007), PD group (ρ = 0.493;
p
= 0.008), and PD-N/MH subgroup (ρ = 0.617;
p
= 0.025). Mann-Whitney U tests demonstrated lower rTHV in PD-SH subgroup compared to both HC group (
p
= 0.013) and PD-N/MH subgroup (
p
= 0.029). Seed-to-voxel rsfMRI analysis revealed reduced hippocampal connectivity in PD-SH subjects compared to HC subjects with a single cluster of voxels.
Conclusions
Although the design of the study do not allow to make firm conclusions, it is reasonable to speculate that the progressive involvement of the hippocampus in PD patients is associated with the progression of OD.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Aged
/ Female
/ Functional magnetic resonance imaging
/ Gender
/ Hippocampus - diagnostic imaging
/ Humans
/ Imaging
/ Magnetic Resonance Imaging - methods
/ Male
/ Medicine
/ Olfaction Disorders - diagnostic imaging
/ Olfaction Disorders - etiology
/ Olfaction Disorders - physiopathology
/ Parkinson Disease - complications
/ Parkinson Disease - diagnostic imaging
