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Editorial: Fetal-Maternal Immune Interactions in Pregnancy
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Editorial: Fetal-Maternal Immune Interactions in Pregnancy
Editorial: Fetal-Maternal Immune Interactions in Pregnancy
Journal Article

Editorial: Fetal-Maternal Immune Interactions in Pregnancy

2019
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Overview
The different cell types, molecules, and their interactions in the placenta that help to nurture, maintain and protect the new life are all important factors in creating a safe environment for the semi-allograft fetus. While self-reactive Treg cells contribute to the maintenance of self-tolerance, paternal antigen-specific T cells control the immune response to paternal antigen expressing cells.Tsuda et al.review the role of regulatory T cells in establishing an appropriate immunological relationship between the mother and the fetus. Kieffer et al.discuss the role of memory T cells in the establishment of tolerance toward allogeneic paternal antigens and their important role in inducing fetal tolerance. Because inflammation is implicated as a causal factor in preeclampsia and because Treg cells are able to control inflammation, the paper ofRobertson et al.discusses the potential therapeutic use of Treg cells. Original research byTwisselmann et al.presents that IgG Fc glycosylation patterns of infants depend on their gestational ages. [...]there is a qualitative shift in the type of IgG Fc glycosylation toward a pro-inflammatory pattern in preterm infants that might contribute to their increased risk for chronic inflammatory diseases such as bronchopulmonary dysplasia.