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Editorial: Leukocyte Trafficking in Homeostasis and Disease
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Editorial: Leukocyte Trafficking in Homeostasis and Disease
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Journal Article
Editorial: Leukocyte Trafficking in Homeostasis and Disease
2019
Overview
The importance of β2 integrins for immune function is shown by rare genetic disorders (Leukocyte adhesion deficiencies, or LAD) that affect their expression (LAD-I) or function (LAD-III, caused by mutations in the integrin regulator, kindlin-3) (8,9). Because of these various roles in immunity, β2 integrin dysfunction can contribute to the development of both immunodeficiency diseases and inflammatory diseases. Focusing on the migratory dynamics of neutrophils,Morikis and Simonsummarize an extensive body of literature suggesting that biomechanical signals at the original site of interactions between leukocytes and the activated endothelium critically regulate leukocyte adhesion and polarization. Because the presence of both signals display potent circadian patterns, the review also discusses how these signals contribute to diurnal rhythms in leukocyte trafficking. Conflict of Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. 1.VestweberD.How leukocytes cross the vascular endothelium.Nat Rev Immunol.
