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Effect of Quinupristin/Dalfopristin on Production of Cytokines by Human Monocytes
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Effect of Quinupristin/Dalfopristin on Production of Cytokines by Human Monocytes
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Journal Article
Effect of Quinupristin/Dalfopristin on Production of Cytokines by Human Monocytes
2000
Overview
The effect of the novel streptogramin antibiotic quinupristin/dalfopristin (synercid) on cytokine production in vitro was examined in monocytes obtained from healthy human volunteers and stimulated with either lipopolysaccharide or heat-killed Staphylococcus aureus (Pansorbin). Synercid at concentrations that are achievable in humans (1, 5, and 10 μg/mL) significantly suppressed production of interleukin (IL)-1α, IL-1β, IL-6, IL-10, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor-α in a concentration-dependent manner. Thus, synercid possesses significant immunomodulatory activity, in addition to its antimicrobial activity.
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
