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“To Anticipate”: Neoadjuvant Therapy in Melanoma with a Focus on Predictive Biomarkers
by
Vitale, Maria Grazia
, Minisini, Alessandro Marco
, Puglisi, Fabio
, Garutti, Mattia
, Rossi, Ernesto
, Schinzari, Giovanni
, Buriolla, Silvia
, Bertoli, Elisa
in
Biomarkers
/ Cancer therapies
/ Chemotherapy
/ Clinical trials
/ Drug dosages
/ Gene expression
/ Immunotherapy
/ Inflammatory bowel disease
/ Lymphatic system
/ Medical prognosis
/ Melanoma
/ Metastasis
/ Patients
/ Response rates
/ Review
/ Studies
/ Surgery
2020
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“To Anticipate”: Neoadjuvant Therapy in Melanoma with a Focus on Predictive Biomarkers
by
Vitale, Maria Grazia
, Minisini, Alessandro Marco
, Puglisi, Fabio
, Garutti, Mattia
, Rossi, Ernesto
, Schinzari, Giovanni
, Buriolla, Silvia
, Bertoli, Elisa
in
Biomarkers
/ Cancer therapies
/ Chemotherapy
/ Clinical trials
/ Drug dosages
/ Gene expression
/ Immunotherapy
/ Inflammatory bowel disease
/ Lymphatic system
/ Medical prognosis
/ Melanoma
/ Metastasis
/ Patients
/ Response rates
/ Review
/ Studies
/ Surgery
2020
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“To Anticipate”: Neoadjuvant Therapy in Melanoma with a Focus on Predictive Biomarkers
by
Vitale, Maria Grazia
, Minisini, Alessandro Marco
, Puglisi, Fabio
, Garutti, Mattia
, Rossi, Ernesto
, Schinzari, Giovanni
, Buriolla, Silvia
, Bertoli, Elisa
in
Biomarkers
/ Cancer therapies
/ Chemotherapy
/ Clinical trials
/ Drug dosages
/ Gene expression
/ Immunotherapy
/ Inflammatory bowel disease
/ Lymphatic system
/ Medical prognosis
/ Melanoma
/ Metastasis
/ Patients
/ Response rates
/ Review
/ Studies
/ Surgery
2020
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“To Anticipate”: Neoadjuvant Therapy in Melanoma with a Focus on Predictive Biomarkers
Journal Article
“To Anticipate”: Neoadjuvant Therapy in Melanoma with a Focus on Predictive Biomarkers
2020
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Overview
Despite surgical resection and adjuvant therapies, stage III melanomas still have a substantial risk of relapse. Neoadjuvant therapy is an emerging strategy that might offer superior efficacy compared to adjuvant therapy. Moreover, neoadjuvant therapy has some virtual advantages: it might allow for less demolitive surgery, permit the in vivo evaluation of drug efficacy, help tailor adjuvant treatments, and play a crucial role in innovative translational research. Herein, we review the available literature to explore the scientific background behind the neoadjuvant approach. We also discuss published clinical trials with a focus on predictive biomarkers and ongoing studies. Finally, we outline a possible framework for future neoadjuvant clinical trial development based on the International Neoadjuvant Melanoma Consortium guidelines.
Publisher
MDPI AG,MDPI
Subject
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