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Immunodominant Domains Present on the Bordetella pertussis Vaccine Component Filamentous Hemagglutinin
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Immunodominant Domains Present on the Bordetella pertussis Vaccine Component Filamentous Hemagglutinin
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Journal Article
Immunodominant Domains Present on the Bordetella pertussis Vaccine Component Filamentous Hemagglutinin
1997
Overview
To identify immunologically important domains on filamentous hemagglutinin (FHA), a Bordetella pertussis protein included in new acellular pertussis vaccines (ACPVs), a series of monoclonal antibodies, sera from infants vaccinated with ACPVs or whole cell pertussis vaccine (WCPV), and sera from patients with pertussis were analyzed by immunoblots containing FHA fragments and recombinant FHA proteins. Immunodominant domains located at the COOH-terminus of FHA (type I domain) and near the NH2-terminus (type II domain) were defined by the reactivity with monoclonal antibodies. The sera from patients with pertussis and sera from infants vaccinated with WCPV or with 6 different investigational ACPVs specifically recognized well-defined regions within the type I and type II domains. Identification of these prominent immunologic epitopes on FHA should be useful for the construction of more well-defined pertussis vaccines and for the interpretation of human serologic responses, which may correlate with efficacy of pertussis vaccines.
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
Adhesins, Bacterial - immunology
/ Biological and medical sciences
/ Bordetella pertussis - immunology
/ Child
/ Epitopes
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Immunodominant Epitopes - analysis
/ Infant
/ Peptide Fragments - immunology
/ Pertussis Vaccine - immunology
/ Recombinant Fusion Proteins - immunology
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
