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Demographic, Ethnic, and Geographic Differences between Human T Cell Lymphotropic Virus (HTLV) Type I-Seropositive Carriers and Persons with HTLV-I Gag-Indeterminate Western Blots in Central Africa
by
Salla, Roger
, Mauclére, Philippe
, Gessain, Antoine
, Mahieux, Renaud
, Mfoupouendoun, Jermie
, Abada, Emmanuel Tina
, Le Hesran, Jean-Yves
, Millan, Jacques
, de Thé, Guy
in
Adolescent
/ Adult
/ Age Factors
/ Antibodies
/ Antibodies, Viral - blood
/ Biological and medical sciences
/ Blood donation
/ Blotting, Western - methods
/ Cameroon - epidemiology
/ Carrier State
/ Child
/ Concise Communications
/ DNA, Viral - blood
/ Female
/ Gene Products, gag
/ Geography
/ HTLV-I Infections - epidemiology
/ HTLV-I Infections - ethnology
/ HTLV-I Infections - virology
/ Human T lymphotropic virus 1
/ Human T-lymphotropic virus 1 - genetics
/ Human T-lymphotropic virus 1 - immunology
/ Human viral diseases
/ Humans
/ Infectious diseases
/ Male
/ Medical sciences
/ Middle Aged
/ Miscellaneous
/ Polymerase chain reaction
/ Reactivity
/ Seroepidemiologic studies
/ T lymphocytes
/ Tropical medicine
/ Tropical regions
/ Viral diseases
/ Viruses
1997
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Demographic, Ethnic, and Geographic Differences between Human T Cell Lymphotropic Virus (HTLV) Type I-Seropositive Carriers and Persons with HTLV-I Gag-Indeterminate Western Blots in Central Africa
by
Salla, Roger
, Mauclére, Philippe
, Gessain, Antoine
, Mahieux, Renaud
, Mfoupouendoun, Jermie
, Abada, Emmanuel Tina
, Le Hesran, Jean-Yves
, Millan, Jacques
, de Thé, Guy
in
Adolescent
/ Adult
/ Age Factors
/ Antibodies
/ Antibodies, Viral - blood
/ Biological and medical sciences
/ Blood donation
/ Blotting, Western - methods
/ Cameroon - epidemiology
/ Carrier State
/ Child
/ Concise Communications
/ DNA, Viral - blood
/ Female
/ Gene Products, gag
/ Geography
/ HTLV-I Infections - epidemiology
/ HTLV-I Infections - ethnology
/ HTLV-I Infections - virology
/ Human T lymphotropic virus 1
/ Human T-lymphotropic virus 1 - genetics
/ Human T-lymphotropic virus 1 - immunology
/ Human viral diseases
/ Humans
/ Infectious diseases
/ Male
/ Medical sciences
/ Middle Aged
/ Miscellaneous
/ Polymerase chain reaction
/ Reactivity
/ Seroepidemiologic studies
/ T lymphocytes
/ Tropical medicine
/ Tropical regions
/ Viral diseases
/ Viruses
1997
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Demographic, Ethnic, and Geographic Differences between Human T Cell Lymphotropic Virus (HTLV) Type I-Seropositive Carriers and Persons with HTLV-I Gag-Indeterminate Western Blots in Central Africa
by
Salla, Roger
, Mauclére, Philippe
, Gessain, Antoine
, Mahieux, Renaud
, Mfoupouendoun, Jermie
, Abada, Emmanuel Tina
, Le Hesran, Jean-Yves
, Millan, Jacques
, de Thé, Guy
in
Adolescent
/ Adult
/ Age Factors
/ Antibodies
/ Antibodies, Viral - blood
/ Biological and medical sciences
/ Blood donation
/ Blotting, Western - methods
/ Cameroon - epidemiology
/ Carrier State
/ Child
/ Concise Communications
/ DNA, Viral - blood
/ Female
/ Gene Products, gag
/ Geography
/ HTLV-I Infections - epidemiology
/ HTLV-I Infections - ethnology
/ HTLV-I Infections - virology
/ Human T lymphotropic virus 1
/ Human T-lymphotropic virus 1 - genetics
/ Human T-lymphotropic virus 1 - immunology
/ Human viral diseases
/ Humans
/ Infectious diseases
/ Male
/ Medical sciences
/ Middle Aged
/ Miscellaneous
/ Polymerase chain reaction
/ Reactivity
/ Seroepidemiologic studies
/ T lymphocytes
/ Tropical medicine
/ Tropical regions
/ Viral diseases
/ Viruses
1997
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Demographic, Ethnic, and Geographic Differences between Human T Cell Lymphotropic Virus (HTLV) Type I-Seropositive Carriers and Persons with HTLV-I Gag-Indeterminate Western Blots in Central Africa
Journal Article
Demographic, Ethnic, and Geographic Differences between Human T Cell Lymphotropic Virus (HTLV) Type I-Seropositive Carriers and Persons with HTLV-I Gag-Indeterminate Western Blots in Central Africa
1997
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Overview
Using stringent Western blot (WB) criteria, human T cell lymphotropic virus (HTLV) type I seroprevalence among 3783 persons from representative rural populations of Cameroon averaged 1.1% and was higher in females (1.5%) and in Pygmies (2.0%), increasing with age. Furthermore, an HTLV-I Gag-indeterminate WB profile (HGIP), exhibiting strong reactivities to p19, p26, p28, p32, p36, and pr 53 but lacking both p24 and env reactivity, was observed in 1.6% of the same populations. The prevalence of the HGIP was similar between males and females, did not increase with age, and appeared to cluster in tropical forests of southern Cameroon, especially among Pygmies (reaching 4%). These contrasting epidemiologic features, together with the lack of detection by polymerase chain reaction of HTLV-I sequences in the peripheral blood mononuclear cells of the persons with HGIP, strongly suggest that such a WB profile does not appear to reflect an HTLV-I-related viral infection but possibly an environmental (viral or parasitic) factor endemic in tropical rain forest areas.
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
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