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Serious Asthma Events with Budesonide plus Formoterol vs. Budesonide Alone
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Journal Article
Serious Asthma Events with Budesonide plus Formoterol vs. Budesonide Alone
2016
Overview
In adolescents and adults with moderate-to-severe asthma, the addition of formoterol to inhaled glucocorticoids was associated with a lower risk of asthma exacerbations than that with glucocorticoids alone and with a similar risk of serious asthma-related events.
Current guidelines for the management of asthma suggest that inhaled glucocorticoids should be used as initial controller therapy, with a long-acting beta-agonist (LABA) then added if symptoms remain uncontrolled or increase in severity.
1
Although LABAs have been an available treatment option for asthma since 1990,
2
questions remain regarding the safety of this drug class.
3
These concerns originate mainly from the results of two large studies in which the effects of adding the LABA salmeterol to existing asthma treatment were reviewed.
4
,
5
These studies showed higher rates of asthma-related death and other serious outcomes related to asthma among patients receiving salmeterol . . .
Publisher
Massachusetts Medical Society
Subject
/ Adrenergic beta-2 Receptor Agonists - administration & dosage
/ Adrenergic beta-2 Receptor Agonists - adverse effects
/ Adult
/ Aged
/ Asthma
/ Asthma - prevention & control
/ Bronchodilator Agents - administration & dosage
/ Bronchodilator Agents - adverse effects
/ Budesonide - administration & dosage
/ Budesonide - adverse effects
/ Child
/ Female
/ Formoterol Fumarate - administration & dosage
/ Formoterol Fumarate - adverse effects
/ Glucocorticoids - administration & dosage
/ Glucocorticoids - adverse effects
/ Humans
/ Inhalers
/ Male
/ Patients
/ Safety
