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A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest

by Quinn, Tom , Miller, Joshua , Deakin, Charles D. , Waddington, Michelle , Mellett-Smith, Adam , Starr, Kath R. , Brown, Martina , Burrow, Emma , Falloon, Jakob , Nolan, Jerry P. , Norman, Chloe , Lall, Ranjit , Perkins, Gavin D. , Michelet, Felix , Walker, Alison , Mills, Carla , Bradley, Gemma , Slowther, Anne-Marie , Whitley, Gregory A. , Osborne, Ria , Spaight, Robert E.S. , Squires, Gemma L. , Foster, Theresa , Smyth, Michael A. , Fothergill, Rachael T. , Couper, Keith , Wright, Adam , Wood, Sara , Dra’gon, Victoria , Evans, Christine , Nwankwo, Henry , Lang, Nigel , Tibbetts, Belinda , Claxton Dip, Andrew , Kearney, Justin , Rees, Nigel , Charlton, Karl , Limmer, Matthew , Williams, Julia , Wiles, Jason V. , Long, John B. , Wiltshire, Sarah , Mason, James M. , Ji, Chen , Bell, Steve , Brown, Shona

in Aged / Aged, 80 and over / Cardiac Arrest / Cardiology / Cardiology General / Cardiopulmonary resuscitation / Clinical Medicine / Clinical Medicine General / Clinical trials / Confidentiality / CPR / Critical Care / Drug therapy / Emergency Medical Services / Emergency Medicine / Emergency Medicine General / Epinephrine - administration & dosage / Epinephrine - adverse effects / Female / Heart / Humans / Hypothesis testing / Infusions, Intraosseous - adverse effects / Infusions, Intraosseous - statistics & numerical data / Injections, Intravenous - adverse effects / Injections, Intravenous - statistics & numerical data / Intravenous administration / Kaplan-Meier Estimate / Length of stay / Male / Middle Aged / Observational studies / Out-of-Hospital Cardiac Arrest - drug therapy / Out-of-Hospital Cardiac Arrest - mortality / Paramedics / Patients / Pulmonary / Quality of life / Research ethics / Return of Spontaneous Circulation - drug effects / Statistical analysis / Survival / Treatment Outcome / United Kingdom / Venous access

2025

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2025

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2025

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Journal Article

A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest

Quinn, Tom,

Miller, Joshua,

Deakin, Charles D.,

Waddington, Michelle,

Mellett-Smith, Adam,

Starr, Kath R.,

Brown, Martina,

Burrow, Emma,

Falloon, Jakob,

Nolan, Jerry P.,

Norman, Chloe,

Lall, Ranjit,

Perkins, Gavin D.,

Michelet, Felix,

Walker, Alison,

Mills, Carla,

Bradley, Gemma,

Slowther, Anne-Marie,

Whitley, Gregory A.,

Osborne, Ria,

Spaight, Robert E.S.,

Squires, Gemma L.,

Foster, Theresa,

Smyth, Michael A.,

Fothergill, Rachael T.,

Couper, Keith,

Wright, Adam,

Wood, Sara,

Dra’gon, Victoria,

Evans, Christine,

Nwankwo, Henry,

Lang, Nigel,

Tibbetts, Belinda,

Claxton Dip, Andrew,

Kearney, Justin,

Rees, Nigel,

Charlton, Karl,

Limmer, Matthew,

Williams, Julia,

Wiles, Jason V.,

Long, John B.,

Wiltshire, Sarah,

Mason, James M.,

Ji, Chen,

Bell, Steve,

Brown, Shona

2025

Overview

In a trial involving adults with out-of-hospital cardiac arrest, an intraosseous-first strategy for vascular access did not result in a higher incidence of 30-day survival than an intravenous-first strategy.

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Publisher

Massachusetts Medical Society

Subject

/ Cardiopulmonary resuscitation

/ Clinical Medicine