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Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer

by Vijapurkar, Ujjwala , Lyman, Gary H , Burton, Paul , Eikelboom, John , Yimer, Habte A , Garcia, David A , Belani, Chandra P , Kakkar, Ajay K , Khorana, Alok A , Wildgoose, Peter , Riess, Hanno , Soff, Gerald A , Vadhan-Raj, Saroj , O’Reilly, Eileen M , Liebman, Howard A , Streiff, Michael B , McBane, Robert , Kuderer, Nicole M , Bauer, Kenneth A , Patel, Jai N , Kaul, Simrati , Wun, Ted

in Administration, Oral / Adult / Aged / Aged, 80 and over / Anticoagulants / Antineoplastic Agents - therapeutic use / Bleeding / Cancer / Disease prevention / Double-Blind Method / Embolism / Factor Xa Inhibitors - adverse effects / Factor Xa Inhibitors - therapeutic use / Female / Health risk assessment / Hemorrhage - chemically induced / Humans / Incidence / Intention to Treat Analysis / Intervention / Kaplan-Meier Estimate / Lymphoma / Male / Middle Aged / Neoplasms - complications / Neoplasms - drug therapy / Oncology / Patients / Risk Factors / Rivaroxaban - adverse effects / Rivaroxaban - therapeutic use / Statistical analysis / Thromboembolism / Thrombosis / Treatment Outcome / Ultrasonic imaging / Veins & arteries / Venous Thromboembolism - etiology / Venous Thromboembolism - prevention & control

2019

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Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer

2019

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Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer

2019

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Journal Article

Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer

Vijapurkar, Ujjwala,

Lyman, Gary H,

Burton, Paul,

Eikelboom, John,

Yimer, Habte A,

Garcia, David A,

Belani, Chandra P,

Kakkar, Ajay K,

Khorana, Alok A,

Wildgoose, Peter,

Riess, Hanno,

Soff, Gerald A,

Vadhan-Raj, Saroj,

O’Reilly, Eileen M,

Liebman, Howard A,

Streiff, Michael B,

McBane, Robert,

Kuderer, Nicole M,

Bauer, Kenneth A,

Patel, Jai N,

Kaul, Simrati,

Wun, Ted

2019

Overview

A placebo-controlled trial assessed the efficacy of rivaroxaban to prevent venous thrombosis in patients with cancer at high risk for thrombosis. The thrombosis rate was lower with rivaroxaban, but for the 180-day assessment period, the difference was not significant. Bleeding was approximately twice as common in the rivaroxaban group.

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Publisher

Massachusetts Medical Society

Subject

Administration, Oral

/ Adult

/ Aged

/ Aged, 80 and over

/ Anticoagulants

/ Antineoplastic Agents - therapeutic use

/ Bleeding