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Randomized Trial of Longer-Term Therapy for Symptoms Attributed to Lyme Disease
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Journal Article
Randomized Trial of Longer-Term Therapy for Symptoms Attributed to Lyme Disease
2016
Overview
In this randomized, controlled trial from Europe involving patients with persistent symptoms attributed to Lyme disease, there was no benefit associated with 12 additional weeks of treatment with either doxycycline or clarithromycin–hydroxychloroquine.
Patients with Lyme disease, which is caused by the
Borrelia burgdorferi
sensu lato complex (including
B. afzelii
and
B. garinii
in Europe), often report persistent symptoms.
1
These symptoms are also referred to as the post–Lyme disease syndrome or chronic Lyme disease and may occur after resolution of an erythema migrans rash or after other — possibly unnoticed — manifestations of early Lyme disease, regardless of whether a patient received initial appropriate antibiotic treatment. Patients present mainly with pain, fatigue, and neurologic or cognitive disturbances.
2
,
3
Previous randomized, clinical trials have not shown convincingly that prolonged antibiotic treatment has beneficial effects . . .
Publisher
Massachusetts Medical Society
Subject
/ Anti-Bacterial Agents - administration & dosage
/ Anti-Bacterial Agents - adverse effects
/ Antimalarials - administration & dosage
/ Antimalarials - adverse effects
/ Clarithromycin - administration & dosage
/ Doxycycline - administration & dosage
/ Drug Administration Schedule
/ Female
/ Humans
/ Hydroxychloroquine - administration & dosage
/ Male
/ Patients
