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Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease
by
Mayes, Maureen D
, Maher, Toby M
, Fischer, Aryeh
, Girard, Mannaig
, Stowasser, Susanne
, Distler, Oliver
, Tetzlaff, Kay
, Gahlemann, Martina
, Raghu, Ganesh
, Azuma, Arata
, Sauter, Wiebke
, Kuwana, Masataka
, Alves, Margarida
, Clerisme-Beaty, Emmanuelle
, Highland, Kristin B
in
Administration, Oral
/ Adult
/ Clinical trials
/ Computed tomography
/ Diarrhea
/ Diarrhea - chemically induced
/ Disease Progression
/ Double-Blind Method
/ Double-blind studies
/ Enzyme inhibitors
/ Enzyme Inhibitors - adverse effects
/ Enzyme Inhibitors - therapeutic use
/ Female
/ Fibrosis
/ Humans
/ Indoles - adverse effects
/ Indoles - therapeutic use
/ Lung diseases
/ Lung Diseases, Interstitial - drug therapy
/ Lung Diseases, Interstitial - etiology
/ Lung Diseases, Interstitial - physiopathology
/ Male
/ Middle Aged
/ Mycophenolic acid
/ Oral administration
/ Patients
/ Protein-tyrosine kinase
/ Protein-Tyrosine Kinases - antagonists & inhibitors
/ Pulmonary fibrosis
/ Pulmonary hypertension
/ Rheumatology
/ Scleroderma
/ Scleroderma, Systemic - complications
/ Scleroderma, Systemic - drug therapy
/ Sensitivity analysis
/ Skin
/ Systemic sclerosis
/ Technical communication
/ Vital Capacity
2019
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Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease
by
Mayes, Maureen D
, Maher, Toby M
, Fischer, Aryeh
, Girard, Mannaig
, Stowasser, Susanne
, Distler, Oliver
, Tetzlaff, Kay
, Gahlemann, Martina
, Raghu, Ganesh
, Azuma, Arata
, Sauter, Wiebke
, Kuwana, Masataka
, Alves, Margarida
, Clerisme-Beaty, Emmanuelle
, Highland, Kristin B
in
Administration, Oral
/ Adult
/ Clinical trials
/ Computed tomography
/ Diarrhea
/ Diarrhea - chemically induced
/ Disease Progression
/ Double-Blind Method
/ Double-blind studies
/ Enzyme inhibitors
/ Enzyme Inhibitors - adverse effects
/ Enzyme Inhibitors - therapeutic use
/ Female
/ Fibrosis
/ Humans
/ Indoles - adverse effects
/ Indoles - therapeutic use
/ Lung diseases
/ Lung Diseases, Interstitial - drug therapy
/ Lung Diseases, Interstitial - etiology
/ Lung Diseases, Interstitial - physiopathology
/ Male
/ Middle Aged
/ Mycophenolic acid
/ Oral administration
/ Patients
/ Protein-tyrosine kinase
/ Protein-Tyrosine Kinases - antagonists & inhibitors
/ Pulmonary fibrosis
/ Pulmonary hypertension
/ Rheumatology
/ Scleroderma
/ Scleroderma, Systemic - complications
/ Scleroderma, Systemic - drug therapy
/ Sensitivity analysis
/ Skin
/ Systemic sclerosis
/ Technical communication
/ Vital Capacity
2019
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Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease
by
Mayes, Maureen D
, Maher, Toby M
, Fischer, Aryeh
, Girard, Mannaig
, Stowasser, Susanne
, Distler, Oliver
, Tetzlaff, Kay
, Gahlemann, Martina
, Raghu, Ganesh
, Azuma, Arata
, Sauter, Wiebke
, Kuwana, Masataka
, Alves, Margarida
, Clerisme-Beaty, Emmanuelle
, Highland, Kristin B
in
Administration, Oral
/ Adult
/ Clinical trials
/ Computed tomography
/ Diarrhea
/ Diarrhea - chemically induced
/ Disease Progression
/ Double-Blind Method
/ Double-blind studies
/ Enzyme inhibitors
/ Enzyme Inhibitors - adverse effects
/ Enzyme Inhibitors - therapeutic use
/ Female
/ Fibrosis
/ Humans
/ Indoles - adverse effects
/ Indoles - therapeutic use
/ Lung diseases
/ Lung Diseases, Interstitial - drug therapy
/ Lung Diseases, Interstitial - etiology
/ Lung Diseases, Interstitial - physiopathology
/ Male
/ Middle Aged
/ Mycophenolic acid
/ Oral administration
/ Patients
/ Protein-tyrosine kinase
/ Protein-Tyrosine Kinases - antagonists & inhibitors
/ Pulmonary fibrosis
/ Pulmonary hypertension
/ Rheumatology
/ Scleroderma
/ Scleroderma, Systemic - complications
/ Scleroderma, Systemic - drug therapy
/ Sensitivity analysis
/ Skin
/ Systemic sclerosis
/ Technical communication
/ Vital Capacity
2019
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Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease
Journal Article
Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease
2019
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Overview
Patients with interstitial lung disease associated with systemic sclerosis were treated with usual care plus placebo or nintedanib. The annual rate of change in forced vital capacity assessed over a 52-week period was −52.4 ml per year with nintedanib and −93.3 ml per year with placebo. There were no differences in other measures of systemic sclerosis.
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Diarrhea
/ Diarrhea - chemically induced
/ Enzyme Inhibitors - adverse effects
/ Enzyme Inhibitors - therapeutic use
/ Female
/ Fibrosis
/ Humans
/ Lung Diseases, Interstitial - drug therapy
/ Lung Diseases, Interstitial - etiology
/ Lung Diseases, Interstitial - physiopathology
/ Male
/ Patients
/ Protein-Tyrosine Kinases - antagonists & inhibitors
/ Scleroderma, Systemic - complications
/ Scleroderma, Systemic - drug therapy
/ Skin
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