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Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis
by
Tao, Ye
, Xing, Changying
, Chen, Jianghua
, Liu, Bi-Cheng
, Hao, Chuanming
, Yin, Aiping
, Wang, Chunrong
, Liao, Yunhua
, Leong, Robert
, Liu, Zhengrong
, Luo, Laimin
, Zuo, Li
, Neff, Thomas
, Peng, Xiaomei
, Yu, Kin-Hung P
, Chen, Nan
, Hao, Li
, Lin, Hongli
, Liang, Xinling
, Liu, Cameron
, Szczech, Lynda
in
Acidosis
/ Acidosis - chemically induced
/ Adult
/ Aged
/ Anemia
/ Anemia - drug therapy
/ Anemia - etiology
/ Cardiovascular disease
/ Cholesterol
/ Cholesterol - blood
/ Dialysis
/ Double-Blind Method
/ Erythropoiesis
/ Erythropoietin
/ Female
/ Glycine - adverse effects
/ Glycine - analogs & derivatives
/ Glycine - therapeutic use
/ Heart failure
/ Hematinics - adverse effects
/ Hematinics - therapeutic use
/ Hemodialysis
/ Hemoglobin
/ Hemoglobins - analysis
/ Hepcidin
/ Homeostasis
/ Humans
/ Hyperkalemia
/ Hyperkalemia - chemically induced
/ Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors
/ Hypoxia-inducible factors
/ Iron
/ Isoquinolines - adverse effects
/ Isoquinolines - therapeutic use
/ Kidney diseases
/ Male
/ Metabolic acidosis
/ Metabolism
/ Middle Aged
/ Patients
/ Prolyl hydroxylase
/ Renal Insufficiency, Chronic - blood
/ Renal Insufficiency, Chronic - complications
2019
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Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis
by
Tao, Ye
, Xing, Changying
, Chen, Jianghua
, Liu, Bi-Cheng
, Hao, Chuanming
, Yin, Aiping
, Wang, Chunrong
, Liao, Yunhua
, Leong, Robert
, Liu, Zhengrong
, Luo, Laimin
, Zuo, Li
, Neff, Thomas
, Peng, Xiaomei
, Yu, Kin-Hung P
, Chen, Nan
, Hao, Li
, Lin, Hongli
, Liang, Xinling
, Liu, Cameron
, Szczech, Lynda
in
Acidosis
/ Acidosis - chemically induced
/ Adult
/ Aged
/ Anemia
/ Anemia - drug therapy
/ Anemia - etiology
/ Cardiovascular disease
/ Cholesterol
/ Cholesterol - blood
/ Dialysis
/ Double-Blind Method
/ Erythropoiesis
/ Erythropoietin
/ Female
/ Glycine - adverse effects
/ Glycine - analogs & derivatives
/ Glycine - therapeutic use
/ Heart failure
/ Hematinics - adverse effects
/ Hematinics - therapeutic use
/ Hemodialysis
/ Hemoglobin
/ Hemoglobins - analysis
/ Hepcidin
/ Homeostasis
/ Humans
/ Hyperkalemia
/ Hyperkalemia - chemically induced
/ Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors
/ Hypoxia-inducible factors
/ Iron
/ Isoquinolines - adverse effects
/ Isoquinolines - therapeutic use
/ Kidney diseases
/ Male
/ Metabolic acidosis
/ Metabolism
/ Middle Aged
/ Patients
/ Prolyl hydroxylase
/ Renal Insufficiency, Chronic - blood
/ Renal Insufficiency, Chronic - complications
2019
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Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis
by
Tao, Ye
, Xing, Changying
, Chen, Jianghua
, Liu, Bi-Cheng
, Hao, Chuanming
, Yin, Aiping
, Wang, Chunrong
, Liao, Yunhua
, Leong, Robert
, Liu, Zhengrong
, Luo, Laimin
, Zuo, Li
, Neff, Thomas
, Peng, Xiaomei
, Yu, Kin-Hung P
, Chen, Nan
, Hao, Li
, Lin, Hongli
, Liang, Xinling
, Liu, Cameron
, Szczech, Lynda
in
Acidosis
/ Acidosis - chemically induced
/ Adult
/ Aged
/ Anemia
/ Anemia - drug therapy
/ Anemia - etiology
/ Cardiovascular disease
/ Cholesterol
/ Cholesterol - blood
/ Dialysis
/ Double-Blind Method
/ Erythropoiesis
/ Erythropoietin
/ Female
/ Glycine - adverse effects
/ Glycine - analogs & derivatives
/ Glycine - therapeutic use
/ Heart failure
/ Hematinics - adverse effects
/ Hematinics - therapeutic use
/ Hemodialysis
/ Hemoglobin
/ Hemoglobins - analysis
/ Hepcidin
/ Homeostasis
/ Humans
/ Hyperkalemia
/ Hyperkalemia - chemically induced
/ Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors
/ Hypoxia-inducible factors
/ Iron
/ Isoquinolines - adverse effects
/ Isoquinolines - therapeutic use
/ Kidney diseases
/ Male
/ Metabolic acidosis
/ Metabolism
/ Middle Aged
/ Patients
/ Prolyl hydroxylase
/ Renal Insufficiency, Chronic - blood
/ Renal Insufficiency, Chronic - complications
2019
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Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis
Journal Article
Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis
2019
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Overview
This phase 3, randomized trial in China compared the efficacy and safety of roxadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, with placebo for anemia in patients with CKD who were not undergoing dialysis. Roxadustat was superior to placebo in increasing and maintaining hemoglobin levels.
Publisher
Massachusetts Medical Society
Subject
/ Acidosis - chemically induced
/ Adult
/ Aged
/ Anemia
/ Dialysis
/ Female
/ Glycine - analogs & derivatives
/ Hematinics - adverse effects
/ Hematinics - therapeutic use
/ Hepcidin
/ Humans
/ Hyperkalemia - chemically induced
/ Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors
/ Iron
/ Isoquinolines - adverse effects
/ Isoquinolines - therapeutic use
/ Male
/ Patients
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