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Hematological evaluation of acquired von Willebrand syndrome before oral surgery: Management of an unusual case
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Hematological evaluation of acquired von Willebrand syndrome before oral surgery: Management of an unusual case
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Journal Article
Hematological evaluation of acquired von Willebrand syndrome before oral surgery: Management of an unusual case
2012
Overview
[1] {Table 1} Treatment with 1-deamino-8-d-arginine-vasopressin (DDAVP) which was administered intravenously at a dose of 0.3 μg/kg did not show a significant improvement in bleeding time (BT), plasma levels of factor VIII, and vWF. [...]he received intravenous infusions of factor VIII/vWF concentrates (Haemate-P; Centeon, Marburg, Germany) at a daily dose of 40 IU/kg until the third postoperative day for an average of five administrations, achieving a shortened BT (from more than 18 min to 8 min) as well as transient correction of factor VIII and vWF plasma levels. [2],[3] The unusual dyscrasia reported here highlights that some AvWS patients may be unresponsive to DDAVP. [...]the replacement therapy with factor VIII/VWF concentrates remains, the sole option of treatment in AvWS patients with IgM-MGUS, although this will produce transitory effects [4] as was the case in our patient.
Publisher
Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Medknow Publications & Media Pvt Ltd,Wolters Kluwer Medknow Publications
