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Risk of Hospitalization for Cardiovascular Disease after Use of Macrolides and Penicillins: A Comparative Prospective Cohort Study
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Risk of Hospitalization for Cardiovascular Disease after Use of Macrolides and Penicillins: A Comparative Prospective Cohort Study
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Journal Article
Risk of Hospitalization for Cardiovascular Disease after Use of Macrolides and Penicillins: A Comparative Prospective Cohort Study
2001
Overview
Chlamydia pneumoniae has been associated with cardiovascular diseases, and C. pneumoniae infection is treatable with macrolides. In this comparative cohort study, 634 users of macrolides and 3827 users of penicillins were identified from the Danish Health Service Registry of Prescriptions and followed up for an average of 6 months. The patients were then linked to the Regional Hospital Discharge Registry to assess the outcome of hospitalization for cardiovascular disease. In the first 3 months, the relative risk (RR) of admission for a cardiovascular disease was 0.48 (95% confidence interval, 0.27–0.88) in users of macrolides compared with users of penicillins. No difference was seen after 3 months. Interaction analyses indicated that the lower risk seen in users of macrolides could be more pronounced in patients without versus those with a previous cardiovascular disease (RR, 0.39 vs. 0.52), in patients ⩾60 versus <60 years old (RR, 0.39 vs. 0.64), and in men versus women (RR, 0.35 vs. 0.67)
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
/ Anti-Bacterial Agents - therapeutic use
/ Atherosclerosis (general aspects, experimental research)
/ Biological and medical sciences
/ Cardiovascular Diseases - epidemiology
/ Cardiovascular Diseases - etiology
/ Cardiovascular Diseases - prevention & control
/ Chlamydia Infections - complications
/ Chlamydia Infections - drug therapy
/ Denmark
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ International Statistical Classification of Diseases
/ Male
/ Penicillins - therapeutic use
/ Virology
