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CD3+CD4-CD8- (Double-Negative) T Cells in Inflammation, Immune Disorders and Cancer
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CD3+CD4-CD8- (Double-Negative) T Cells in Inflammation, Immune Disorders and Cancer
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Journal Article
CD3+CD4-CD8- (Double-Negative) T Cells in Inflammation, Immune Disorders and Cancer
2022
Overview
The crucial role of CD4
+
and CD8
+
T cells in shaping and controlling immune responses during immune disease and cancer development has been well established and used to achieve marked clinical benefits. CD3
+
CD4
-
CD8
-
double-negative (DN) T cells, although constituting a rare subset of peripheral T cells, are gaining interest for their roles in inflammation, immune disease and cancer. Herein, we comprehensively review the origin, distribution and functions of this unique T cell subgroup. First, we focused on characterizing multifunctional DN T cells in various immune responses. DN regulatory T cells have the capacity to prevent graft-versus-host disease and have therapeutic value for autoimmune disease. T helper-like DN T cells protect against or promote inflammation and virus infection depending on the specific settings and promote certain autoimmune disease. Notably, we clarified the role of DN tumor-infiltrating lymphocytes and outlined the potential for malignant proliferation of DN T cells. Finally, we reviewed the recent advances in the applications of DN T cell-based therapy for cancer. In conclusion, a better understanding of the heterogeneity and functions of DN T cells may help to develop DN T cells as a potential therapeutic tool for inflammation, immune disorders and cancer.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
