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Tezepelumab in Adults with Severe Chronic Rhinosinusitis with Nasal Polyps

by Lipworth, Brian J. , Mankad, Vaishali S. , Margolis, Mary Kay , Ponnarambil, Sandhia S. , Han, Joseph K. , Almqvist, Gun , McLaren, Julie , Megally, Ayman , Desrosiers, Martin , Mullol, Joaquim , Bahadori, Lila , Jagadeesh, Shankar , Hopkins, Claire , Lee, Stella E. , Li, Ting , Hellqvist, Åsa , Pfaar, Oliver , MacKay, Jamie , Chen, Claudia

in Adult / Allergy / Antibodies, Monoclonal, Humanized - administration & dosage / Antibodies, Monoclonal, Humanized - adverse effects / Asthma / Autoimmune Disease / Chronic Disease - drug therapy / Clinical Medicine / Clinical Medicine General / Critical Care / Critical Care General / Cytokines / Diaries / Double-Blind Method / Endoscopy / Endoscopy - statistics & numerical data / Female / Glucocorticoids / Glucocorticoids - administration & dosage / Humans / Immunology / Immunology General / Inflammatory Disease / Injections, Subcutaneous / Male / Middle Aged / Nasal Polyps - complications / Nasal Polyps - diagnosis / Nasal Polyps - drug therapy / Nasal Polyps - surgery / Olfaction Disorders - diagnosis / Olfaction Disorders - drug therapy / Olfaction Disorders - etiology / Olfaction Disorders - surgery / Otolaryngology / Otolaryngology General / Otorhinolaryngologic Surgical Procedures - statistics & numerical data / Outpatient-Based Clinical Medicine / Paranasal sinus / Patients / Placebos / Polyps / Pulmonary / Respiratory diseases / Rheumatology / Rheumatology General / Rhinosinusitis / Rhinosinusitis - complications / Rhinosinusitis - diagnosis / Rhinosinusitis - drug therapy / Rhinosinusitis - surgery / Severity of Illness Index / Sino-Nasal Outcome Test / Sinuses / Statistical analysis / Surgery / T-Cells / Treatment Outcome

2025

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Tezepelumab in Adults with Severe Chronic Rhinosinusitis with Nasal Polyps

2025

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Tezepelumab in Adults with Severe Chronic Rhinosinusitis with Nasal Polyps

2025

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Journal Article

Tezepelumab in Adults with Severe Chronic Rhinosinusitis with Nasal Polyps

Lipworth, Brian J.,

Mankad, Vaishali S.,

Margolis, Mary Kay,

Ponnarambil, Sandhia S.,

Han, Joseph K.,

Almqvist, Gun,

McLaren, Julie,

Megally, Ayman,

Desrosiers, Martin,

Mullol, Joaquim,

Bahadori, Lila,

Jagadeesh, Shankar,

Hopkins, Claire,

Lee, Stella E.,

Li, Ting,

Hellqvist, Åsa,

Pfaar, Oliver,

MacKay, Jamie,

Chen, Claudia

2025

Overview

In patients with chronic severe rhinosinusitis and nasal polyps, tezepelumab therapy led to greater reductions in polyp size and nasal congestion and less use of surgery and glucocorticoids than placebo.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Allergy

/ Antibodies, Monoclonal, Humanized - administration & dosage

/ Antibodies, Monoclonal, Humanized - adverse effects

/ Asthma

/ Autoimmune Disease

/ Chronic Disease - drug therapy