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High hsCRP Concentration Is Associated With Acute Pancreatitis in Multifactorial Chylomicronemia Syndrome
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High hsCRP Concentration Is Associated With Acute Pancreatitis in Multifactorial Chylomicronemia Syndrome
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Journal Article
High hsCRP Concentration Is Associated With Acute Pancreatitis in Multifactorial Chylomicronemia Syndrome
2024
Overview
Abstract
Background
Multifactorial chylomicronemia syndrome (MCS) is a severe form of hypertriglyceridemia (hyperTG) associated with an increased risk of acute pancreatitis. However, the risk of acute pancreatitis is very heterogenous in MCS. Previous studies suggested that inflammation might promote disease progression in hyperTG-induced acute pancreatitis.
Objective
To determine if low-grade inflammation is associated with acute pancreatitis in MCS.
Methods
This study included 102 subjects with MCS for whom high-sensitivity C-reactive protein (hsCRP) concentration was measured at their first visit at the Montreal Clinical Research Institute.
Results
Patients with MCS who had a previous history of acute pancreatitis had a significant higher hsCRP concentration (4.62 mg/L vs 2.61 mg/L; P = .003), and high hsCRP concentration (≥ 3 mg/L) was independently associated with acute pancreatitis prevalence (P < .05). Up to 64% of the variability in acute pancreatitis prevalence was explained by the maximal triglycerides (TG) concentration, hsCRP concentration, the presence of rare variants in TG-related genes, and fructose intake, based on a stepwise multivariate regression model (P < .0001).
Conclusion
This retrospective study showed for the first time that hsCRP concentration is strongly associated with acute pancreatitis prevalence in MCS. It also suggests that low-grade inflammation may be a driver of acute pancreatitis in severe hypertriglyceridemia. Prospective studies could help determine the causality of this association and assess whether medication known to reduce low-grade inflammation could help prevent acute pancreatitis in individuals with severe hypertriglyceridemia.
Publisher
Oxford University Press
Subject
/ Adult
/ Aged
/ C-Reactive Protein - analysis
/ C-Reactive Protein - metabolism
/ Female
/ Fructose
/ Humans
/ Hyperlipoproteinemia Type I - blood
/ Hyperlipoproteinemia Type I - complications
/ Hyperlipoproteinemia Type I - epidemiology
/ Hypertriglyceridemia - blood
/ Hypertriglyceridemia - complications
/ Hypertriglyceridemia - epidemiology
/ Male
