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Apoplexy accompanying pituitary adenoma as a complication of preoperative anterior pituitary function tests
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Apoplexy accompanying pituitary adenoma as a complication of preoperative anterior pituitary function tests
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Apoplexy accompanying pituitary adenoma as a complication of preoperative anterior pituitary function tests
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Journal Article
Apoplexy accompanying pituitary adenoma as a complication of preoperative anterior pituitary function tests
2007
Overview
Pituitary apoplexy occurs as a very rare complication of the pituitary function test. We have experienced two cases of pituitary apoplexy following anterior pituitary function tests for preoperative assessment: a triple bolus test and a TRH test. To elucidate such a rare complication, we outline our two cases and review 28 cases from the literature. The clinical characteristics, etiology, pathophysiology, and diagnostic and therapeutic implications are also discussed. The combined data suggest that pituitary function tests have the potential to precipitate pituitary apoplexy, and its manifestations range from a clinically benign event to a catastrophic presentation with permanent neurological deficits or even death, although most patients may fortunately have a good outcome. We suggest that the pituitary function test should not be done as a routine test, and when such a test is planned, the patient should be observed with caution for any symptomatic changes for at least 2 hours following the test for appropriate treatment. Further, MRI, especially enhanced studies, may provide an earlier diagnosis of the pituitary apoplexy since CT scan images often fail to demonstrate either density changes or obvious enlargement of the pituitary adenoma at the acute stage.
Publisher
Springer Nature B.V
Subject
Adenoma, Acidophil - diagnosis
/ Adenoma, Acidophil - surgery
/ Adult
/ Aged
/ Female
/ Gonadotropin-Releasing Hormone - adverse effects
/ Humans
/ Male
/ Pituitary Apoplexy - chemically induced
/ Pituitary Apoplexy - diagnosis
/ Pituitary Apoplexy - surgery
/ Pituitary Function Tests - adverse effects
/ Pituitary Neoplasms - diagnosis
/ Pituitary Neoplasms - surgery
/ Surgery
