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$Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma$

Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma

by Munshi, Nikhil C , Raje, Noopur , Weisel, Katja , Cavo, Michele , Moreau, Philippe , Reece, Donna , Goldschmidt, Hartmut , Delforge, Michel , Yakoub-Agha, Ibrahim , Kaiser, Shari , Berdeja, Jesús , Connarn, Jamie N , San-Miguel, Jesús , Huang, Liping , Anderson, Larry D , Patel, Payal , Lonial, Sagar , Shah, Nina , Madduri, Deepu , Rambaldi, Alessandro , Petrocca, Fabio , Massaro, Monica , Hege, Kristen , Oriol, Albert , Campbell, Timothy B , Siegel, David , Lin, Yi , Einsele, Hermann

in Adult / Aged / Antigens / Biomarkers - blood / Bone marrow / CD38 antigen / Cell therapy / Chimeric antigen receptors / Cytokine Release Syndrome - etiology / Cytokines / Drug dosages / Drug Resistance, Neoplasm / FDA approval / Female / Hematologic Diseases - chemically induced / Humans / Immunomodulation / Immunotherapy, Adoptive - adverse effects / Lymphocytes / Lymphocytes B / Lymphocytes T / Male / Middle Aged / Minimal residual disease / Multiple myeloma / Multiple Myeloma - immunology / Multiple Myeloma - therapy / Neurotoxicity / Neutropenia / Pharmacokinetics / Progression-Free Survival / Proteasome inhibitors / Receptors, Chimeric Antigen - therapeutic use / Recurrence / Thrombocytopenia

2021

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Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma

2021

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$Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma$

Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma

2021

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$Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma$

Journal Article

Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma

Munshi, Nikhil C,

Raje, Noopur,

Weisel, Katja,

Cavo, Michele,

Moreau, Philippe,

Reece, Donna,

Goldschmidt, Hartmut,

Delforge, Michel,

Yakoub-Agha, Ibrahim,

Kaiser, Shari,

Berdeja, Jesús,

Connarn, Jamie N,

San-Miguel, Jesús,

Huang, Liping,

Anderson, Larry D,

Patel, Payal,

Lonial, Sagar,

Shah, Nina,

Madduri, Deepu,

Rambaldi, Alessandro,

Petrocca, Fabio,

Massaro, Monica,

Hege, Kristen,

Oriol, Albert,

Campbell, Timothy B,

Siegel, David,

Lin, Yi,

Einsele, Hermann

2021

Overview

Autologous T cells engineered to express a chimeric antigen receptor specific for the B-cell maturation antigen produced responses in the majority of patients with refractory and resistant myeloma, including deep molecular responses in 26% of treated patients. High-grade hematologic toxic effects and cytokine release syndrome were common.

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Publisher

Massachusetts Medical Society

Subject

/ Aged