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Mortality in the 4-Year Trial of Tiotropium (UPLIFT) in Patients with Chronic Obstructive Pulmonary Disease
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Mortality in the 4-Year Trial of Tiotropium (UPLIFT) in Patients with Chronic Obstructive Pulmonary Disease
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Journal Article
Mortality in the 4-Year Trial of Tiotropium (UPLIFT) in Patients with Chronic Obstructive Pulmonary Disease
2009
Overview
In the 4-year UPLIFT trial, tiotropium improved lung function and health-related quality of life and decreased exacerbations compared with usual respiratory medications except inhaled anticholinergics in patients with chronic obstructive pulmonary disease (COPD). Mortality and its causes was a secondary endpoint in UPLIFT.
We describe the effect of tiotropium on survival and analyze differences between mortality during treatment and during follow-up of discontinued patients.
This study involved a randomized, double-blind trial comparing tiotropium with placebo in patients with COPD (>or=40 yr of age; postbronchodilator FEV(1)
Publisher
Am Thoracic Soc,American Thoracic Society,Oxford University Press
Subject
/ Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
/ Biological and medical sciences
/ Cholinergic Antagonists - administration & dosage
/ Cholinergic Antagonists - therapeutic use
/ Chronic obstructive pulmonary disease
/ Chronic obstructive pulmonary disease, asthma
/ Female
/ Humans
/ Male
/ Patients
/ Pulmonary Disease, Chronic Obstructive - drug therapy
/ Pulmonary Disease, Chronic Obstructive - mortality
/ Scopolamine Derivatives - administration & dosage
/ Scopolamine Derivatives - therapeutic use
/ Smoking
