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The ins and outs of selective kinase inhibitor development
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The ins and outs of selective kinase inhibitor development
The ins and outs of selective kinase inhibitor development
Journal Article

The ins and outs of selective kinase inhibitor development

2015
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Overview
Protein kinases have emerged as one of the most successful families of drug targets. To date, most selective kinase inhibitors have been discovered serendipitously either through broad selectivity screening or through the discovery of unique binding modes. Here we discuss design strategies that could lead to a broader coverage of the kinome with selective inhibitors and to a more rational approach for developing them.