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The ins and outs of selective kinase inhibitor development
by
Knapp, Stefan
, Gray, Nathanael S
, Müller, Susanne
, Chaikuad, Apirat
in
631/535/1266
/ 631/67
/ 631/92/275
/ 631/92/613
/ Allosteric Site
/ Biochemical Engineering
/ Biochemistry
/ Bioorganic Chemistry
/ Catalytic Domain
/ Cell Biology
/ Chemistry
/ Chemistry/Food Science
/ commentary
/ Crystallography, X-Ray
/ Drug Approval
/ Drug Design
/ Drug Discovery
/ Drug therapy
/ Humans
/ Kinases
/ Protein Conformation
/ Protein Kinase Inhibitors - chemical synthesis
/ Protein Kinase Inhibitors - chemistry
/ Protein Kinases - chemistry
/ Proteins
/ Quantitative Structure-Activity Relationship
/ Small Molecule Libraries - chemical synthesis
/ Small Molecule Libraries - chemistry
/ United States
/ United States Food and Drug Administration
2015
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The ins and outs of selective kinase inhibitor development
by
Knapp, Stefan
, Gray, Nathanael S
, Müller, Susanne
, Chaikuad, Apirat
in
631/535/1266
/ 631/67
/ 631/92/275
/ 631/92/613
/ Allosteric Site
/ Biochemical Engineering
/ Biochemistry
/ Bioorganic Chemistry
/ Catalytic Domain
/ Cell Biology
/ Chemistry
/ Chemistry/Food Science
/ commentary
/ Crystallography, X-Ray
/ Drug Approval
/ Drug Design
/ Drug Discovery
/ Drug therapy
/ Humans
/ Kinases
/ Protein Conformation
/ Protein Kinase Inhibitors - chemical synthesis
/ Protein Kinase Inhibitors - chemistry
/ Protein Kinases - chemistry
/ Proteins
/ Quantitative Structure-Activity Relationship
/ Small Molecule Libraries - chemical synthesis
/ Small Molecule Libraries - chemistry
/ United States
/ United States Food and Drug Administration
2015
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Do you wish to request the book?
The ins and outs of selective kinase inhibitor development
by
Knapp, Stefan
, Gray, Nathanael S
, Müller, Susanne
, Chaikuad, Apirat
in
631/535/1266
/ 631/67
/ 631/92/275
/ 631/92/613
/ Allosteric Site
/ Biochemical Engineering
/ Biochemistry
/ Bioorganic Chemistry
/ Catalytic Domain
/ Cell Biology
/ Chemistry
/ Chemistry/Food Science
/ commentary
/ Crystallography, X-Ray
/ Drug Approval
/ Drug Design
/ Drug Discovery
/ Drug therapy
/ Humans
/ Kinases
/ Protein Conformation
/ Protein Kinase Inhibitors - chemical synthesis
/ Protein Kinase Inhibitors - chemistry
/ Protein Kinases - chemistry
/ Proteins
/ Quantitative Structure-Activity Relationship
/ Small Molecule Libraries - chemical synthesis
/ Small Molecule Libraries - chemistry
/ United States
/ United States Food and Drug Administration
2015
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The ins and outs of selective kinase inhibitor development
Journal Article
The ins and outs of selective kinase inhibitor development
2015
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Overview
Protein kinases have emerged as one of the most successful families of drug targets. To date, most selective kinase inhibitors have been discovered serendipitously either through broad selectivity screening or through the discovery of unique binding modes. Here we discuss design strategies that could lead to a broader coverage of the kinome with selective inhibitors and to a more rational approach for developing them.
Publisher
Nature Publishing Group US,Nature Publishing Group
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