Asset Details
Do you wish to reserve the book?
Deep brain stimulation modulates directional limbic connectivity in major depressive disorder
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Deep brain stimulation modulates directional limbic connectivity in major depressive disorder
Do you wish to request the book?
Deep brain stimulation modulates directional limbic connectivity in major depressive disorder
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Deep brain stimulation modulates directional limbic connectivity in major depressive disorder
2025
Overview
Deep brain stimulation (DBS) is being investigated as a treatment for patients with refractory major depressive disorder (MDD). However, little is known about how DBS exerts its antidepressive effects. Here, we investigated whether ventral anterior limb of the internal capsule stimulation modulates a limbic network centered around the amygdala in patients with treatment-resistant MDD.
Nine patients underwent resting state functional magnetic resonance scans before DBS surgery and after 1 year of treatment. In addition, they were scanned twice within 2 weeks during the subsequent double-blind cross-over phase with active and sham treatment. Twelve matched controls underwent scans at the same time intervals to account for test-retest effects. The imaging data were investigated with functional connectivity (FC) analysis and dynamic causal modelling.
Results showed that 1 year of DBS treatment was associated with increased FC of the left amygdala with precentral cortex and left insula, along with decreased bilateral connectivity between nucleus accumbens and ventromedial prefrontal cortex. No changes in FC were observed during the cross-over phase. Effective connectivity analyses using dynamic causal models revealed widespread amygdala-centric changes between presurgery and 1 year follow-up, while the cross-over phase was associated with insula-centric changes between active and sham stimulation.
These results suggest that ventral anterior limb of the internal capsule DBS results in complex rebalancing of the limbic network involved in emotion, reward, and interoceptive processing.
Publisher
Cambridge University Press
Subject
/ Amygdala
/ Amygdala - diagnostic imaging
/ Brain
/ Changes
/ Cortex
/ Deep Brain Stimulation - methods
/ Depressive Disorder, Major - diagnostic imaging
/ Depressive Disorder, Major - physiopathology
/ Depressive Disorder, Major - therapy
/ Depressive Disorder, Treatment-Resistant - diagnostic imaging
/ Depressive Disorder, Treatment-Resistant - physiopathology
/ Depressive Disorder, Treatment-Resistant - therapy
/ Depressive personality disorders
/ Female
/ Humans
/ Internal Capsule - physiopathology
/ Limbic System - physiopathology
/ Limbs
/ Male
/ Nucleus Accumbens - physiopathology
/ Obsessive compulsive disorder
/ Original
/ Patients
/ Prefrontal Cortex - physiopathology
/ Resting
/ Stimuli
/ Surgery
