Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing

by Jiang, Man , Jain, Neeraj , Cho, Byoung-kyu , Camarillo, Jeannie M. , Li, Sheng , Parsa, Sara , Mohan, Prathibha , De Stanchina, Elisa , Birsoy, Kivanc , Thomas, Paul M. , Kelleher, Neil L. , Garcia-Bermudez, Javier , Kuo, David , Tam, Wayne , Socci, Nicholas , Dogan, Ahmet , Wang, Jiahui , Zhao, Chunying , Teater, Matt , Melnick, Ari M. , Reznik, Ed , Pasion, Joyce P. , Ortega-Molina, Ana , Green, Michael R. , Ying, Hsia-Yuan , Wendel, Hans-Guido , Wang, Shenqiu , Ciriello, Giovanni

in Cell Proliferation - genetics / Chromosomes / DNA methylation / Enzymes / Epigenesis, Genetic / Epigenetics / Flow cytometry / Gene expression / Glycine Hydroxymethyltransferase - genetics / Humans / Lymphoma / Lymphoma - genetics / Metabolism / Mutation / Proto-Oncogene Proteins c-bcl-2 - genetics / Statistical significance / Tumors

2020

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing

2020

Confirm

Do you wish to request the book?

The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing

2020

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing

Jiang, Man,

Jain, Neeraj,

Cho, Byoung-kyu,

Camarillo, Jeannie M.,

Li, Sheng,

Parsa, Sara,

Mohan, Prathibha,

De Stanchina, Elisa,

Birsoy, Kivanc,

Thomas, Paul M.,

Kelleher, Neil L.,

Garcia-Bermudez, Javier,

Kuo, David,

Tam, Wayne,

Socci, Nicholas,

Dogan, Ahmet,

Wang, Jiahui,

Zhao, Chunying,

Teater, Matt,

Melnick, Ari M.,

Reznik, Ed,

Pasion, Joyce P.,

Ortega-Molina, Ana,

Green, Michael R.,

Ying, Hsia-Yuan,

Wendel, Hans-Guido,

Wang, Shenqiu,

Ciriello, Giovanni

2020

Overview

Cancer cells adapt their metabolic activities to support growth and proliferation. However, increased activity of metabolic enzymes is not usually considered an initiating event in the malignant process. Here, we investigate the possible role of the enzyme serine hydroxymethyltransferase-2 (SHMT2) in lymphoma initiation. localizes to the most frequent region of copy number gains at chromosome 12q14.1 in lymphoma. Elevated expression of cooperates with in lymphoma development; loss or inhibition of impairs lymphoma cell survival. SHMT2 catalyzes the conversion of serine to glycine and produces an activated one-carbon unit that can be used to support -adenosyl methionine synthesis. SHMT2 induces changes in DNA and histone methylation patterns leading to promoter silencing of previously uncharacterized mutational genes, such as and Together, our findings reveal that amplification of in cooperation with is sufficient in the initiation of lymphomagenesis through epigenetic tumor suppressor silencing.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group

Subject

Cell Proliferation - genetics

/ Chromosomes

/ DNA methylation

/ Enzymes

/ Epigenesis, Genetic

/ Epigenetics

/ Flow cytometry