Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy

by Wang, Leighanne , Abdel-Gadir, Azza , Li, Ning , Dong, Xiaoxi , Wang, Sen , Spielman, Sara , Harb, Hani , Crestani, Elena , DiBenedetto, Nicholas , Chatila, Talal A , Stephen-Victor, Emmanuel , Gerber, Georg K , Umetsu, Dale T , Bry, Lynn , Rima Rachid , Magali Noval Rivas , Secor, William , Biehl, Heather

in Allergies / Clonal deletion / Commensals / Consortia / Dysbacteriosis / Fecal microflora / Food / Food allergies / Immunoglobulin A / Immunoglobulin E / Immunological tolerance / Immunomodulation / Infants / Lymphocytes / Lymphocytes T / Mice / Microbiota / MyD88 protein / Therapy

2019

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy

2019

Confirm

Do you wish to request the book?

Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy

2019

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy

Wang, Leighanne,

Abdel-Gadir, Azza,

Li, Ning,

Dong, Xiaoxi,

Wang, Sen,

Spielman, Sara,

Harb, Hani,

Crestani, Elena,

DiBenedetto, Nicholas,

Chatila, Talal A,

Stephen-Victor, Emmanuel,

Gerber, Georg K,

Umetsu, Dale T,

Bry, Lynn,

Rima Rachid,

Magali Noval Rivas,

Secor, William,

Biehl, Heather

2019

Overview

The role of dysbiosis in food allergy (FA) remains unclear. We found that dysbiotic fecal microbiota in FA infants evolved compositionally over time and failed to protect against FA in mice. Infants and mice with FA had decreased IgA and increased IgE binding to fecal bacteria, indicative of a broader breakdown of oral tolerance than hitherto appreciated. Therapy with Clostridiales species impacted by dysbiosis, either as a consortium or as monotherapy with Subdoligranulum variabile, suppressed FA in mice as did a separate immunomodulatory Bacteroidales consortium. Bacteriotherapy induced expression by regulatory T (Treg) cells of the transcription factor ROR-γt in a MyD88-dependent manner, which was deficient in FA infants and mice and ineffectively induced by their microbiota. Deletion of Myd88 or Rorc in Treg cells abrogated protection by bacteriotherapy. Thus, commensals activate a MyD88/ROR-γt pathway in nascent Treg cells to protect against FA, while dysbiosis impairs this regulatory response to promote disease.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group

Subject

/ Food