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Favipiravir and Ribavirin Treatment of Epidemiologically Linked Cases of Lassa Fever

by Wolf, Timo , Kann, Gerrit , Schuettfort, Gundolf , Rabenau, Holger , Strecker, Thomas , Brown, Shelley , Varkey, Jay B. , Becker, Stephan , Kraft, Colleen S. , Klena, John D. , McElroy, Anita , Lyon, G. Marshall , Patel, Ketan , Ströher, Ute , Vanairsdale, Sharon , Faber, Kelly , Morales, Andres , Stephan, Christoph , Rollin, Pierre E. , Raabe, Vanessa N. , Eickmann, Markus , Mehta, Aneesh K. , Nichol, Stuart , Ribner, Bruce S. , De Leuw, Philipp

in Adult / Amides - therapeutic use / Antiretroviral drugs / Antiviral Agents - therapeutic use / Antiviral drugs / BRIEF REPORTS / Disease transmission / Epidemiology / Fever / Humans / Lassa fever / Lassa Fever - drug therapy / Lassa Fever - physiopathology / Lassa Fever - virology / Lassa virus - genetics / Male / Patients / Polymerase Chain Reaction / Pyrazines - therapeutic use / Ribavirin / Ribavirin - therapeutic use / Ribonucleic acid / RNA / RNA viruses / RNA, Viral - analysis / RNA, Viral - genetics / Semen / Sexual behavior / Sexual transmission / Togo / Viruses

2017

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Favipiravir and Ribavirin Treatment of Epidemiologically Linked Cases of Lassa Fever

2017

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2017

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Journal Article

Favipiravir and Ribavirin Treatment of Epidemiologically Linked Cases of Lassa Fever

Wolf, Timo,

Kann, Gerrit,

Schuettfort, Gundolf,

Rabenau, Holger,

Strecker, Thomas,

Brown, Shelley,

Varkey, Jay B.,

Becker, Stephan,

Kraft, Colleen S.,

Klena, John D.,

McElroy, Anita,

Lyon, G. Marshall,

Patel, Ketan,

Ströher, Ute,

Vanairsdale, Sharon,

Faber, Kelly,

Morales, Andres,

Stephan, Christoph,

Rollin, Pierre E.,

Raabe, Vanessa N.,

Eickmann, Markus,

Mehta, Aneesh K.,

Nichol, Stuart,

Ribner, Bruce S.,

De Leuw, Philipp

2017

Overview

Two patients with Lassa fever are described who are the first human cases treated with a combination of ribavirin and favipiravir. Both patients survived but developed transaminitis and had prolonged detectable virus RNA in blood and semen, suggesting that the possibility of sexual transmission of Lassa virus should be considered.

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Publisher

Oxford University Press

Subject

Adult

/ Amides - therapeutic use

/ Antiretroviral drugs

/ Antiviral Agents - therapeutic use

/ Antiviral drugs

/ BRIEF REPORTS

/ Disease transmission