Asset Details
Do you wish to reserve the book?
Application of 18 β -glycyrrhetinic acid Fluorescent probes in cell imaging
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Application of 18 β -glycyrrhetinic acid Fluorescent probes in cell imaging
Do you wish to request the book?
Application of 18 β -glycyrrhetinic acid Fluorescent probes in cell imaging
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Application of 18 β -glycyrrhetinic acid Fluorescent probes in cell imaging
2026
Overview
Fluorescently labelled small molecule probes (fluorescent probes) play an important role in cell imaging and are often used in combination with light-affinity probes to determine the subcellular localisation of target proteins. To investigate the target proteins of 18
-glycyrrhetinic acid (18
-GA), which regulates the macrophage inflammatory response, we designed and synthesised three types of fluorescent probes. We analysed its structure-activity relationship by evaluating the biological activity and screening for fluorescent probes with high activity. Our results showed that modifying C-3 hydroxyl and C-30 carboxyl groups enhanced the anti-inflammatory activity of 18
-GA, and found that two preferred probes had similar effects on LPS-induced, inflammation-related factor release (IL-1β, TNF-α, IL-6, HDAC8, P-STAT3, and SOCS3) to those of 18
-GA. Fluorescence signals of the preferred probes
and
were observed in the cytoplasm. The above results indicated that the anti-inflammatory site of 18
-GA may be located in proteins in the cytoplasm, which would provide useful information for research on the anti-inflammatory targets of 18
-GA.
Publisher
Taylor & Francis,Taylor & Francis Group
Subject
/ Animals
/ Dose-Response Relationship, Drug
/ Fluorescent Dyes - chemical synthesis
/ Fluorescent Dyes - chemistry
/ Fluorescent Dyes - pharmacology
/ Glycyrrhetinic Acid - analogs & derivatives
/ Glycyrrhetinic Acid - chemical synthesis
/ Glycyrrhetinic Acid - chemistry
/ Glycyrrhetinic Acid - pharmacology
/ Humans
/ Lipopolysaccharides - antagonists & inhibitors
/ Lipopolysaccharides - pharmacology
/ Mice
