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Effect of vitamin A supplementation on the urinary retinol excretion in very low birth weight infants
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Effect of vitamin A supplementation on the urinary retinol excretion in very low birth weight infants
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Journal Article
Effect of vitamin A supplementation on the urinary retinol excretion in very low birth weight infants
2016
Overview
Despite high-dose vitamin A supplementation of very low birth weight infants (VLBW, <1500 g), their vitamin A status does not improve substantially. Unknown is the impact of urinary retinol excretion on the serum retinol concentration in these infants. Therefore, the effect of high-dose vitamin A supplementation on the urinary vitamin A excretion in VLBW infants was investigated. Sixty-three VLBW infants were treated with vitamin A (5000 IU intramuscular, 3 times/week for 4 weeks); 38 untreated infants were classified as control group. On days 3 and 28 of life, retinol, retinol-binding protein 4 (RBP4), glomerular filtration rate, proteinuria, and Tamm–Horsfall protein were quantified in urine. On day 3 of life, substantial retinol and RBP4 losses were found in both groups, which significantly decreased until day 28. Notwithstanding, the retinol excretion was higher (
P
< 0.01) under vitamin A supplementation as compared to infants of the control group. On day 28 of life, the urinary retinol concentrations were predictive for serum retinol concentrations in the vitamin A treated (
P
< 0.01), but not in the control group (
P
= 0.570).
Conclusion
: High urinary retinol excretion may limit the vitamin A supplementation efficacy in VLBW infants. Advanced age and thus postnatal kidney maturation seems to be an important contributor in the prevention of urinary retinol losses.
What is Known:
•
VLBW infants have low vitamin A status
,
even after 4
-
week high
-
dose vitamin A supplementation
[Longardt AC, Eur J Clin Nutr
2014
; Schmiedchen B, Longardt AC, Buehrer C, Raila J, Loui A, Schweigert FJ Neonatology 105:155-160,
2014
]
•
VLBW infants excrete high amounts of retinol
[Nagl B, Loui A, Raila J, Felderhoff-Mueser U, Obladen M, Schweigert FJ Pediatr Nephrol 24:61-66,
2009
]
What is New:
•
Urine retinol excretion reduces with increasing age of VLBW infants and is not suitable to assess vitamin A status in VLBW infants
•
High urinary retinol excretion may limit vitamin A supplementation efficacy in VLBW infants
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
