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Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease
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Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease
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Journal Article
Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease
2011
Overview
In mice, T regulatory (T
reg
) cells show considerable phenotypic and functional plasticity. David Hafler and his colleagues report that the frequency of human T
reg
cells expressing IFN-γ is increased in the peripheral blood of individuals with multiple sclerosis. These T
reg
cells possess reduced suppressive activity, and
in vitro
studies suggest that IL-12 promotes the development of a T helper type 1–like phenotype.
CD4
+
CD25
high
CD127
low/–
forkhead box p3 (Foxp3)
+
regulatory T cells (T
reg
cells) possess functional plasticity. Here we describe a higher frequency of T helper type 1 (T
H
1)-like, interferon-γ (IFN-γ)-secreting Foxp3
+
T cells in untreated subjects with relapsing remitting multiple sclerosis (RRMS) as compared to healthy control individuals. In subjects treated with IFN-β, the frequency of IFN-γ
+
Foxp3
+
T cells is similar to that in healthy control subjects.
In vitro
, human T
reg
cells from healthy subjects acquire a T
H
1-like phenotype when cultured in the presence of interleukin-12 (IL-12). T
H
1-like T
reg
cells show reduced suppressive activity
in vitro
, which can partially be reversed by IFN-γ–specific antibodies or by removal of IL-12.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Biomedical and Life Sciences
/ Forkhead Transcription Factors - immunology
/ Forkhead Transcription Factors - physiology
/ Humans
/ Immunity, Cellular - immunology
/ Interferon-beta - therapeutic use
/ Interferon-gamma - immunology
/ Multiple Sclerosis, Relapsing-Remitting - drug therapy
/ Multiple Sclerosis, Relapsing-Remitting - immunology
/ T-Lymphocytes, Regulatory - immunology
