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Dietary di(2-ethylhexyl)phthalate-impaired glucose metabolism in experimental animals
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Dietary di(2-ethylhexyl)phthalate-impaired glucose metabolism in experimental animals
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Journal Article
Dietary di(2-ethylhexyl)phthalate-impaired glucose metabolism in experimental animals
2006
Overview
The effects of chronic intake of di(2-ethylhexyl)phthalate (DEHP) on the main intermediate glycolytic metabolites in liver and gastrocnemius muscle were investigated in experimental animals. Male Wistar rats (90 -100 g) were fed for 21 days either with a standard chow or the same diet supplemented with 2% (w/w) of DEHP. The DEHP-fed rats had an altered in vivo glucose tolerance associated with abnormal glucose intermediate metabolite contents in liver and skeletal muscle. In these rats, the hepatic content of glucose-6 -phosphate (G-6 -P), fructose-6 -phosphate, pyruvate, lactate, glucose-1 -phosphate and glycogen decreased. At the same time, the G-6 -P content decreased while the pyruvate and lactate levels increased in skeletal muscle. These data, along with the high plasma glucose concentration and the normal lactate blood levels of this group, could indicate that DEHP-fed rats could present a deficiency in muscle glucose and lactate transport, a reduction of the flux through muscle hexokinase and hepatic glucokinase, and a reduction in glycogen synthesis.
Publisher
SAGE Publications,Arnold,Sage Publications Ltd
Subject
/ Animals
/ Biological and medical sciences
/ Diethylhexyl Phthalate - administration & dosage
/ Diethylhexyl Phthalate - adverse effects
/ Enzymes
/ Glucose
/ Liver
/ Male
/ Muscle, Skeletal - drug effects
/ Muscle, Skeletal - metabolism
/ Plasma
/ Plasticizers - administration & dosage
/ Plasticizers - adverse effects
/ Rats
/ Rodents
/ Toxins
