Asset Details
Do you wish to reserve the book?
The hypoxic ventilatory response and arousal burden predict the magnitude of ventilatory long‐term facilitation in humans with obstructive sleep apnoea
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The hypoxic ventilatory response and arousal burden predict the magnitude of ventilatory long‐term facilitation in humans with obstructive sleep apnoea
Do you wish to request the book?
The hypoxic ventilatory response and arousal burden predict the magnitude of ventilatory long‐term facilitation in humans with obstructive sleep apnoea
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The hypoxic ventilatory response and arousal burden predict the magnitude of ventilatory long‐term facilitation in humans with obstructive sleep apnoea
2026
Overview
The magnitude of progressive augmentation (PA) and ventilatory long‐term facilitation (vLTF) are two forms of respiratory plasticity that are enhanced in some humans with obstructive sleep apnoea (OSA). This response might be linked to repeated nocturnal exposure to intermittent hypoxia or other traits connected to OSA. A meta‐analysis was completed using data from 91 OSA participants who completed one of two mild intermittent hypoxia protocols during wakefulness. Two iterations of a subset regression analysis were completed to identify the best model that predicted the magnitude of PA or vLTF. Novel (e.g., arousal and hypoxic burden) or standard indicators of sleep apnoea (e.g., apnoea/hypopnoea index), anthropometric variables, protocol elements and physiological variables measured during wake and sleep were included as independent variables. After model selection, a multiple linear regression analysis was used to identify the most impactful variables in the model. The hypoxic ventilatory response (HVR) alone ( R = 0.589, P < 0.001) or in combination with the arousal index ( R = 0.625, P < 0.015 for both variables) predicted the magnitude of PA, whilst the HVR in combination with the arousal burden ( R = 0.602, P < 0.001) or arousal index ( R = 0.593, P < 0.002 for all variables) predicted the magnitude of vLTF. The HVR and markers of arousal are strong predictors of the magnitude of PA and vLTF. In contrast, markers of apnoea severity, including the hypoxic burden, did not add to the ability to predict the magnitude of PA or vLTF. What is the central question of this study? The goal of this meta‐analysis was to provide insight into the mechanisms that impact the magnitude of progressive augmentation (PA) and ventilatory long‐term facilitation (vLTF) in order to predict the response to treatment with mild intermittent hypoxia in patients living with obstructive sleep apnoea. What is the main finding and its importance The findings suggest that peripheral chemoreflex sensitivity to hypoxia influences the magnitude of PA and vLTF. In addition, besides intermittent hypoxia, stimuli that activate neural pathways involved in both the arousal response and the initiation of respiratory plasticity might also contribute to enhancing the magnitude of PA or vLTF.
Publisher
John Wiley & Sons, Inc,Wiley
Subject
