Journal Article

Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8+ T cells responding to infection

Bergsbaken, Tessa, Bevan, Michael J

2015

Overview

Tissue-resident memory T cells (T RM cells) provide rapid frontline protection from reinfection. Bergsbaken and Bevan identify a gut T RM cell population generated via an unconventional pathway that is protective against a natural mouse intestinal pathogen. We report that oral infection with Yersinia pseudotuberculosis results in the development of two distinct populations of pathogen-specific CD8 + tissue-resident memory T cells (T RM cells) in the lamina propria. CD103 − T cells did not require transforming growth factor-β (TGF-β) signaling but were true resident memory cells. Unlike CD103 + CD8 + T cells, which were TGF-β dependent and were scattered in the tissue, CD103 − CD8 + T cells clustered with CD4 + T cells and CX3CR1 + macrophages and/or dendritic cells around areas of bacterial infection. CXCR3-dependent recruitment of cells to inflamed areas was critical for development of the CD103 − population and pathogen clearance. Our studies have identified the 'preferential' development of CD103 − T RM cells in inflammatory microenvironments within the lamina propria and suggest that this subset has a critical role in controlling infection.

• Publisher: Nature Publishing Group US,Nature Publishing Group
• Subject: 13/31 / 13/51 / 631/250/2152/1566/2493 / 631/250/347 / 64/110 / 64/60 / Animals / Antigens, CD - genetics / Antigens, CD - immunology / Bacterial diseases / Biomedicine / CD4-Positive T-Lymphocytes - immunology / CD4-Positive T-Lymphocytes - microbiology / CD4-Positive T-Lymphocytes - pathology / CD8-Positive T-Lymphocytes - immunology / CD8-Positive T-Lymphocytes - microbiology / CD8-Positive T-Lymphocytes - pathology / Cell Movement / Cellular Microenvironment / Dendritic Cells - immunology / Dendritic Cells - microbiology / Dendritic Cells - pathology / Gene Expression Regulation / Immunologic Memory / Immunology / Immunophenotyping / Infectious Diseases / Integrin alpha Chains - deficiency / Integrin alpha Chains - genetics / Integrin alpha Chains - immunology / Intestinal Mucosa - immunology / Intestinal Mucosa - microbiology / Intestinal Mucosa - pathology / Macrophages - immunology / Macrophages - microbiology / Macrophages - pathology / Mice / Mice, Inbred C57BL / Mice, Knockout / Microenvironments / Pathogens / Receptors, CXCR3 - genetics / Receptors, CXCR3 - immunology / Signal Transduction / Transforming Growth Factor beta - genetics / Transforming Growth Factor beta - immunology / Yersinia pseudotuberculosis - immunology / Yersinia pseudotuberculosis Infections - genetics / Yersinia pseudotuberculosis Infections - immunology / Yersinia pseudotuberculosis Infections - microbiology / Yersinia pseudotuberculosis Infections - pathology