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Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy

by van Woensel, Job B. M. , Idro, Richard , Deijs, Martin , Namazzi, Ruth , Jebbink, Maarten F. , Kootstra, Neeltje A. , Edridge, Arthur W. D. , de Jong, Menno D. , Cristella, Cosimo , Buluma, Linda R. , van Hensbroek, Michael Boele , van der Hoek, Lia , Maurer, Irma

in BRIEF REPORTS / Bunyaviridae Infections - diagnosis / Bunyaviridae Infections - virology / Cerebrospinal Fluid - virology / Child, Preschool / Encephalitis, Viral - diagnosis / Encephalitis, Viral - virology / Female / Genotype / Humans / Metagenomics / Orthobunyavirus - classification / Orthobunyavirus - genetics / Orthobunyavirus - isolation & purification / Uganda

2019

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Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy

2019

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Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy

2019

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Journal Article

Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy

van Woensel, Job B. M.,

Idro, Richard,

Deijs, Martin,

Namazzi, Ruth,

Jebbink, Maarten F.,

Kootstra, Neeltje A.,

Edridge, Arthur W. D.,

de Jong, Menno D.,

Cristella, Cosimo,

Buluma, Linda R.,

van Hensbroek, Michael Boele,

van der Hoek, Lia,

Maurer, Irma

2019

Overview

A Ugandan child with an unexplained encephalitis was investigated using viral metagenomics. Several sequences from all segments of a novel orthobunyavirus were found. The S-segment, used for typing, showed 41% amino acid diversity to its closest relative. The virus was named Ntwetwe virus, after the hometown of the patient.

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Publisher

Oxford University Press

Subject

BRIEF REPORTS

/ Bunyaviridae Infections - diagnosis

/ Bunyaviridae Infections - virology

/ Cerebrospinal Fluid - virology

/ Child, Preschool

/ Encephalitis, Viral - diagnosis

/ Encephalitis, Viral - virology