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Impact of Inosine Triphosphatase Gene Variants on the Risk of Anemia in HIV/Hepatitis C Virus-Coinfected Patients Treated for Chronic Hepatitis C
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Impact of Inosine Triphosphatase Gene Variants on the Risk of Anemia in HIV/Hepatitis C Virus-Coinfected Patients Treated for Chronic Hepatitis C
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Impact of Inosine Triphosphatase Gene Variants on the Risk of Anemia in HIV/Hepatitis C Virus-Coinfected Patients Treated for Chronic Hepatitis C
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Journal Article
Impact of Inosine Triphosphatase Gene Variants on the Risk of Anemia in HIV/Hepatitis C Virus-Coinfected Patients Treated for Chronic Hepatitis C
2011
Overview
The role of rs1127354/rs7270101 alleles at the inosine triphosphatase (ITPA) gene on ribavirin-induced anemia was assessed in 74 human immunodeficiency virus/hepatitis C virus-coinfected patients. Anemia developed in 80% of patients with normal compared to 33% of those with reduced ITPA activity. In contrast, ITPA variants did not influence sustained virological response.
The role of rs1127354/rs7270101 alleles at the inosine triphosphatase (ITPA) gene on ribavirin-induced anemia was assessed in 74 patients with hepatitis C virus and human immunodeficiency virus coinfection. Anemia developed in 80% of patients with normal ITPA activity compared with 33% of those with reduced ITPA activity. In contrast, ITPA variants did not influence sustained virological response.
Publisher
Oxford University Press
Subject
/ Alleles
/ Anemia
/ Antiviral Agents - administration & dosage
/ Antiviral Agents - adverse effects
/ Biological and medical sciences
/ Dosage
/ Female
/ Hematologic and hematopoietic diseases
/ Hepatitis C, Chronic - complications
/ Hepatitis C, Chronic - drug therapy
/ HIV
/ HIV Infections - complications
/ HIV Infections - drug therapy
/ Human immunodeficiency virus
/ Humans
/ Male
/ Pyrophosphatases - metabolism
/ Ribavirin - administration & dosage
/ Viral diseases of the lymphoid tissue and the blood. Aids
/ Viruses
