Journal Article

Whole body and regional body composition analysis by dual-energy X-ray absorptiometry in cirrhotic patients

De Lorenzo, A, Fiore, P, Lionetti, R, Capocaccia, L, Montagnese, F, Riggio, O, Merli, M, Andreoli, A, Diana, F, Meddi, P

1997

Overview

Objectives: To compare whole body and regional (arms, legs and trunk) fat mass, fat-free mineral-free mass, bone mineral content and bone mineral density, measured by DXA, in cirrhotic patients and age, sex and BMI matched healthy volunteers. Design: Cross-sectional study. Setting: Two medical research institutions. Subjects: Twenty-two non ascitic cirrhotic patients and 16 age, sex and BMI matched healthy volunteers. Interventions: The Lunar DPX whole-body X-ray densitometer with Lunar software version 3.6z (Lunar Radiation Corp., Madison WI, USA) was used. Regional analysis was performed on the arms, legs, trunk and head. Results: Compared to controls, cirrhotic patients showed a significant reduction in percentage body fat. When differentiated by gender, however, the reduction in percentage body fat was evident in female cirrhotics only, particularly in the trunk. In male cirrhotic patients fat-free mineral-free mass was reduced in absolute terms in the whole body and the limbs. For both genders and in each body segment bone mineral content and density were reduced in cirrhotics compared to controls. In cirrhotic patients bone mineral density was significantly correlated to both fat-free, mineral-free mass (r=0.85; P <0.001) and to the Physical Activity Index (r=0.52; P <0.0l). Conclusions: Two different patterns of soft tissue loss may be found in cirrhotic patients: in women lean tissue is maintained while fat stores are reduced, as in early starvation; in men lean tissue is reduced, as seen under conditions of stress. Moreover, factors influencing lean body mass, such as nutritional depletion and physical inactivity, may contribute to the reduction of bone density frequently observed in cirrhotic patients.

• Publisher: Nature Publishing,Nature Publishing Group
• Subject: Absorptiometry, Photon / Biological and medical sciences / Body Composition / Body fat / Body mass index / Bone density / Bone mass / Bone mineral content / Bone mineral density / Case-Control Studies / cirrhosis / Cross-Sectional Studies / Densitometers / Depletion / Dual energy X-ray absorptiometry / Fat-free / Fat-free body mass / Female / Gastroenterology. Liver. Pancreas. Abdomen / gender differences / Humans / Lean body mass / Liver Cirrhosis / Liver Cirrhosis - diagnostic imaging / Liver Cirrhosis - physiopathology / Liver. Biliary tract. Portal circulation. Exocrine pancreas / Lunar radiation / Male / Medical research / Medical sciences / Men / Middle Aged / Other diseases. Semiology / Patients / Physical activity / physiopathology / radiography / Regional analysis / Regional planning / Research facilities / Research institutions / Severity of Illness Index / Sex / Sexes / Soft tissues / Tissues / women / X-rays