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Perfusion differences on SPECT and PWI in patients with acute ischemic stroke
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Perfusion differences on SPECT and PWI in patients with acute ischemic stroke
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Journal Article
Perfusion differences on SPECT and PWI in patients with acute ischemic stroke
2009
Overview
Introduction
The purposes of the present study were to compare the flow defect volumes on perfusion-weighted magnetic resonance imaging (PWI) and
99m
Tc-labeled ethylcysteinate dimer (
99m
Tc-ECD) single photon emission computed tomography (SPECT) at acute and subacute stages of ischemic stroke and to analyze the relationship between the detected flow defects on the two methods and neurological status and clinical outcomes.
Methods
Perfusion defects on PWI and SPECT were measured within 48 h and on day 8 of the onset of stroke from 22 patients with their first-ever acute supratentorial ischemic stroke. The primary neurological status was evaluated prior to the imaging. Clinical outcome was assessed at 3 months after the onset of the stroke.
Results
The volumes of cerebral blood flow (CBF) defects did not differ between SPECT and PWI within the 48-h examinations. However, the volume of CBF defect was significantly larger on SPECT than on PWI on day 8 (
p
= 0.03). Within the 48-h examinations, the CBF defect volumes on SPECT and PWI were comparably related to the neurological status. On day 8, the CBF defect volume on SPECT showed higher correlation to the neurological status and more precisely predicted the clinical outcomes at 3 months than PWI.
Conclusions
99m
TC-ECD-SPECT and PWI both have ability to detect cerebral hypoperfusion in patients with ischemic stroke but with some differences. The value of SPECT is more accurate in terms of the delayed outcome, such as prognosis and rehabilitation planning.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
Subject
/ Adult and adolescent clinical studies
/ Aged
/ Biological and medical sciences
/ Brain
/ Brain Ischemia - diagnostic imaging
/ Brain Ischemia - physiopathology
/ Circle of Willis - diagnostic imaging
/ Circle of Willis - physiopathology
/ Female
/ Humans
/ Imaging
/ Investigative techniques, diagnostic techniques (general aspects)
/ Magnetic Resonance Angiography
/ Male
/ Medicine
/ Psychology. Psychoanalysis. Psychiatry
/ Radiodiagnosis. Nmr imagery. Nmr spectrometry
/ Stroke
