Asset Details
Do you wish to reserve the book?
B regulatory cells and the tumor-promoting actions of TNF-α during squamous carcinogenesis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
B regulatory cells and the tumor-promoting actions of TNF-α during squamous carcinogenesis
Do you wish to request the book?
B regulatory cells and the tumor-promoting actions of TNF-α during squamous carcinogenesis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
B regulatory cells and the tumor-promoting actions of TNF-α during squamous carcinogenesis
2011
Overview
The inflammatory cytokine TNF-α has been recognized as a critical tumor promoter, but the effector cells that mediate its action have not been fully characterized. Because B cells regulate squamous and prostate carcinogenesis, and Tnf-/- mice harbor B-cell defects, we investigated the hypothesis that B cells are important effector cells for TNF-α—mediated promotion of cancer development. Using an adoptive transfer strategy and the 7,12-dimethylbenz[α]anthracene/terephthalic acid (DMBA/TPA) two-stage model of skin carcinogenesis, we found that both B cells and TNF-α are critical for the development of DMBA/TPA-induced papilloma. Transfer of B cells from DMBA/TPA-treated wild-type mice to Tnf-/- mice rescued papilloma development to a wild-type level, a result not observed when B cells from Tnf-/- mice were transferred to Rag2-/- mice or when TNF-α was eliminated selectively in B cells. Resistance to papilloma development in Tnf-/- mice was associated with increased IFN-γ and CD8+ T cells in skin and a significant reduction in IL-10—producing B regulatory cells alongside an increase in IFN-γ—producing CD8+ T cells in the spleen. These data indicate that during DMBA/TPA-induced squamous carcinogenesis TNF-α mediates tumor-promoting activity via regulatory B cells that repress antitumor immunity.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
9,10-Dimethyl-1,2-benzanthracene - toxicity
/ Animals
/ Cancer
/ Carcinoma, Squamous Cell - chemically induced
/ Carcinoma, Squamous Cell - immunology
/ Carcinoma, Squamous Cell - pathology
/ immunity
/ Mice
/ Skin Neoplasms - chemically induced
/ Tumor Necrosis Factor-alpha - genetics
/ Tumor Necrosis Factor-alpha - physiology
/ Tumors
