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Role of syndecan-3 polymorphisms in obesity and female hyperandrogenism
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Role of syndecan-3 polymorphisms in obesity and female hyperandrogenism
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Journal Article
Role of syndecan-3 polymorphisms in obesity and female hyperandrogenism
2009
Overview
The heparan sulfate proteoglycan syndecan-3 (
SDC3
) is a novel regulator of feeding behavior and body weight. Recently, an association of
SDC3
polymorphisms with obesity has been observed in Koreans. As female obesity is associated with hyperandrogenism and infertility, we studied the role of
SDC3
polymorphisms in female individuals undergoing diagnostics prior to infertility treatment. For this purpose, endocrine parameters and body mass index of 249 women were assessed. Genotyping of V208I, D303N, and T329I was performed with TaqMan technology using lymphocyte-derived DNA and allelic discrimination polymerase chain reaction. Chi-square test, Student’s
t
test, and one-way analysis of variance were used for statistical analysis. We find that an infrequent genotype and allele variation of T329I correlated with obesity (
p
= 0.028). Genotype and alleles of V208I were associated with luteinizing hormone (
p
= 0.007 and
p
= 0.001, respectively), luteinizing hormone/follicle-stimulating hormone (
p
= 0.002 and
p
< 0.005, respectively), 17 hydroxyprogesterone (
p
= 0.007 and
p
= 0.001, respectively), androstenedione (
p
= 0.046 and
p
= 0.013, respectively), and sex hormone-binding globulin (
p
= 0.021). We conclude that marked ethnic differences of the
SDC3
SNP distribution in our European population could account for correlations less predominant compared to Koreans. While infrequent variations of T329I correlated with obesity, V208I was associated with endocrine parameters related to hyperandrogenism. These findings indicate that
SDC3
polymorphisms could contribute to the link between female hyperandrogenism and obesity and suggest a novel potential role for
SDC3
as a modulator of gonadal steroid function.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
