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Dynamic MRI of the small bowel: usefulness of quantitative contrast-enhancement parameters and time–signal intensity curves for differentiating between active and inactive Crohn’s disease
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Dynamic MRI of the small bowel: usefulness of quantitative contrast-enhancement parameters and time–signal intensity curves for differentiating between active and inactive Crohn’s disease
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Dynamic MRI of the small bowel: usefulness of quantitative contrast-enhancement parameters and time–signal intensity curves for differentiating between active and inactive Crohn’s disease
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Journal Article
Dynamic MRI of the small bowel: usefulness of quantitative contrast-enhancement parameters and time–signal intensity curves for differentiating between active and inactive Crohn’s disease
2010
Overview
Purpose
To assess Crohn’s disease (CD) activity through analysis of time–signal intensity curves and quantitative contrast-enhancement parameters on dynamic contrast-enhanced MRI.
Materials and methods
70 patients (male:female = 44:26, age 15–45 years, mean 27.8 years) with biopsy-proven clinically active or inactive CD, underwent dynamic contrast-enhanced MRI after oral administration of iso-osmotic solution. Time–signal intensity curves were classified according to their shape as type I (early upslope with late plateau) and type II (slow contrast material wash-in with late wash-out). Curve parameters such as maximum enhancement (ME), the ratio between late and ME (LE/ME), and UpSlope (US) were compared between patients with active and inactive CD (two-tailed Mann–Whitney test). Sensitivity, specificity, and cut-off for each parameter were calculated by means of receiver operating characteristic curve (ROC) analysis.
Results
53/53 patients with active CD and 17/17 with inactive CD showed type I and type II curves, respectively. ME, LE/ME, and US were significantly higher in active than in inactive CD. ME, LE/ME, and US had sensitivity and specificity of 100%:100%:100% and 100%:83%:100% with cut-offs of 135.5:0.8909:2, respectively.
Conclusions
Qualitative and quantitative analysis of time–signal intensity curves obtained with dynamic contrast-enhanced MRI allow reliable noninvasive differentiation between active and inactive CD.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
