Journal Article

Nutraceutical, Anti-Inflammatory, and Immune Modulatory Effects of β-Glucan Isolated from Yeast

Anjum, Aftab Ahmad, Bacha, Umar, Iqbal, Sanaullah, Nasir, Muhammad

2017

Overview

β -Glucan is a dietary fibre, found in many natural sources, and controls chronic metabolic diseases effectively. However, β-glucan from the yeast has rarely been investigated. Objectively, conditions were optimized to isolate β-glucan from the yeast (max. 66% yield); those optimized conditions included 1.0 M NaOH, pH 7.0, and 90°C. The purity and identity of the isolated β-glucan were characterized through FT-IR, SEM, DSC, and physicofunctional properties. The obtained results from DSC revealed highly stable β-glucan (m.p., 125°C) with antioxidant activity (TAC value 0.240 ± 0.0021 µg/mg, H2O2 scavenging 38%), which has promising bile acid binding 40.463% and glucose control (in vitro). In line with these results, we evaluated the in vivo anti-inflammatory potential, that is, myeloperoxidase activity and reduction in MDA and NO; protective effect on proteins and keeping viscosity within normal range exhibited improvement. Also, the in vivo cholesterol binding and reduction in the skin thickness by β-glucan were highly encouraging. Finally, our results confirmed that yeast β-glucan is effective against some of the inflammatory and oxidative stress markers studied in this investigation. In general, the effect of 4% β-glucan was more noticeable versus 2% β-glucan. Therefore, our results support the utilization of β-glucan as a novel, economically cheap, and functional food ingredient.

• Publisher: Hindawi Publishing Corporation,Hindawi,John Wiley & Sons, Inc
• Subject: Animal sciences / Anti-Inflammatory Agents - pharmacology / Antioxidants / Antioxidants - metabolism / beta-Glucans - metabolism / Binding / Biomass / Biomedical research / Cholesterol / Chronic illnesses / Dehydroascorbic Acid - analogs & derivatives / Dehydroascorbic Acid - metabolism / Dermatitis / Diabetes / Dietary fiber / Dietary Supplements / Food / Fourier transforms / Functional foods & nutraceuticals / Glucan / Glucose - metabolism / Hydrogen peroxide / Immunologic Factors - pharmacology / Inflammation / Metabolic disorders / Nitric Oxide - metabolism / Oxidation-Reduction - drug effects / Oxidative stress / Oxidative Stress - drug effects / Peroxidase / pH effects / Pharmacology / Proteins / Public health / Scanning electron microscopy / Scavenging / Skin / Studies / Temperature / Toxicology / Viscosity / Viscosity - drug effects / Yeast / Yeasts - metabolism / β-Glucan